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About Bolder Science

Our mission is to provide healthcare professionals with unbiased clinical research information, easily.

Currently, you can access the following clinical trials being conducted worldwide:

370533 studies
in
219 countries
Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 04/16/2021.
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Clinical Trials of Interest

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Drug Interventions

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Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 04/16/2021.
Displaying: 370,533 trials in your specialties ()
View trials across your selected specialties

Sorafenib Tosylate in Treating Patients With Metastatic, Locally Advanced, or Recurrent Medullary Thyroid Cancer

  • Status
    Active, not recruiting
  • Phase
    Phase 2
  • Condition
    Hereditary Thyroid Gland Medullary Carcinoma, Multiple Endocrine ...
View Full Trial
INTERVENTION

Drug: Sorafenib Tosylate

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Washington University School of Medicine, Saint Louis, Missouri, United States

Brief Summary

This phase II trial studies how well sorafenib tosylate works in treating patients with medullary thyroid cancer that has spread to other parts of the body (metastatic), spread to the tissue surrounding the thyroid (locally advanced), or has returned after a period of improvement (recurrent). Sorafenib tosylate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.

CAR-T Cells in Treating Patients With Relapsed or Refractory NHL

  • Status
    Recruiting
  • Phase
    Early Phase 1
  • Condition
    Refractory Indolent Adult Non-Hodgkin Lymphoma
View Full Trial
INTERVENTION

Drug: CD19 CAR-T, Drug: CD22 CAR-T, Drug: CD19+CD22 CAR-T, Drug: Fludarabine, Drug: Cyclophosphamide

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

No.2 Hospital of Hebei Medical University, Shijiazhuang, Hebei, China

Brief Summary

This is an open, single-arm, phase I clinical study to evaluate efficacy and safety of chimeric antigen receptor T cell immunotherapy (CAR-T) in the treatment of Non-hodgkin's lymphoma. A total of 100 patients are planned to be enrolled over a period of 3 years.

Prevention With Chloroquine in Health Personnel Exposed to Infection With Coronavirus Disease 2019 (COVID-19) (TS-COVID)

  • Status
    Active, not recruiting
  • Phase
    Phase 2
  • Condition
    Covid19
View Full Trial
INTERVENTION

Drug: Chloroquine

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Fundacion Valle del Lili, Cali, Valle Del Cauca, Colombia

Brief Summary

The purpose of this study is to assess the efficacy and safety of chloroquine prophylaxis on the incidence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infections in healthcare workers exposed to patients with confirmed Coronavirus Disease 2019 (COVID-19)

A Study Evaluating the Efficacy and Safety of CKD-314 in Hospitalized Adult Patients Diagnosed With COVID-19 Pneumonia

  • Status
    Not yet recruiting
  • Phase
    Phase 2
  • Condition
    COVID-19
View Full Trial
INTERVENTION

Drug: Nafamostat Mesilate

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Brief Summary

The primary objective of this study is to evaluate the efficacy of CKD-314 (Nafabelltan) compared to standard of care (SOC), with respect to clinical status assessed by a 7-point ordinal scale in hospitalized adult patients diagnosed with COVID-19 pneumonia

Bendamustine, Rituximab and Acalabrutinib in Waldenstrom's Macroglobulinemia

  • Status
    Not yet recruiting
  • Phase
    Phase 2
  • Condition
    Waldenstrom Macroglobulinemia
View Full Trial
INTERVENTION

Drug: Acalabrutinib, Drug: Bendamustine, Drug: Rituximab

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Brief Summary

This is a multi-centre, open label, single-arm, phase II clinical trial in untreated patients with Waldenstrom's Macroglobulinemia. Symptomatic, previously untreated patients will receive SOC bendamustine and rituximab for 6 28-day cycles. Bendamustine will be given intravenously at 90 mg/m2 on days 1 and 2 of each cycle. Rituximab will be given on day 1 of each cycle (375 mg/m2 intravenously for the first cycle and 1400 mg subcutaneously OR 375 mg/m2 intravenously for subsequent cycles (as per institutional procedures)). Concomitantly, partcipants will receive 100 mg of the investigational product, acalabrutinib, orally for 1 year (365 days) at 100 mg BID.

Lenvatinib and Pembrolizumab in Resectable Mucosal Melanoma

  • Status
    Not yet recruiting
  • Phase
    Phase 2
  • Condition
    Neoadjuvant Treatment, Mucosal Melanoma
View Full Trial
INTERVENTION

Drug: Lenvatinib, Pembrolizumab

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Beijing Cancer Hospital, Beijing, Beijing, China

Brief Summary

This study is a randomized ,single center clinical study which is designed to investigate whether combination of Pembrolizumab with Lenvatinib could improve pCR rate and consequent survival in resectable mucosal melanoma. All the eligible patients were assigned to receive Lenvatinib once a day (QD) for 6 weeks plus pembrolizumab on Day 1 of each 21-day cycle (Q3W) concurrently on days 1 and 22, followed by surgery and 18 cycles of Pembrolizumab 200mg q3w of adjuvant phase.

A Study of SHR-A1811 in Subjects With Advanced Malignant Solid Tumors

  • Status
    Recruiting
  • Phase
    Phase 1
  • Condition
    Advanced Solid Tumors
View Full Trial
INTERVENTION

Drug: SHR-A1811

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Macquarie University Hospital, Macquarie, New South Wales, Australia

Brief Summary

This is an open-label, two-part study to evaluate the safety, tolerability, pharmacokinetics and immunogenicity of SHR-A1811 and preliminary anti-tumor efficacy in HER2 expressing or mutated advanced malignant solid tumor subjects.

Use of Jet-injection in Photodynamic Therapy for Basal Cell Carcinoma

  • Status
    Recruiting
  • Phase
    Phase 2
  • Condition
    BCC - Basal Cell Carcinoma, Basal Cell Carcinoma, BCC, Basal Cell...
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INTERVENTION

Drug: Jet injection of ALA, Procedure: Surgical excision, Procedure: Illumination, Other: Incubation

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Memorial Sloan Kettering Cancer Center, New York, New York, United States

Brief Summary

The purpose of this study is to find out whether injecting ALA into the skin with a jet-injection device and activating the drug with light is a safe treatment that causes few or mild side effects in people with basal cell carcinoma.

A Trial Investigating the Pharmacokinetic and Pharmacodynamic Properties of Insulin Icodec in Subjects With Type 2 Diabetes

  • Status
    Recruiting
  • Phase
    Phase 1
  • Condition
    Diabetes Mellitus, Type 2
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INTERVENTION

Drug: Insulin Icodec

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Novo Nordisk Investigational Site, Graz, Austria

Brief Summary

The aim of the study is to improve clinical outcomes for patients with type 2 diabetes by limiting the burden associated with insulin treatment. Participants will get insulin degludec as well as insulin icodec - Insulin icodec is a new medicine while insulin degludec is commonly used and prescribed by doctors. Participants will administer subcutaneous injections of insulin degludec once daily for at least one week (7 injections) but this period may be extended up to 8 weeks. Thereafter, once weekly subcutaneous injections of insulin icodec will follow, resulting in a total of at least 8 but not more than 16 subcutaneous injections of icodec. The study will last for about 17-32 weeks Participants will have at least 5 in-house visits (where participants will stay at the clinic) and 17 outpatient visits with the study doctor. Women cannot take part if pregnant, breast-feeding or plan to become pregnant during the study period.

GD2 CAR T Cells in Diffuse Intrinsic Pontine Gliomas(DIPG) & Spinal Diffuse Midline Glioma(DMG)

  • Status
    Recruiting
  • Phase
    Phase 1
  • Condition
    Glioma of Spinal Cord, Glioma of Brainstem
View Full Trial
INTERVENTION

Drug: Fludarabine, Drug: Cyclophosphamide, Drug: GD2 CAR T cells

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Lucile Packard Children's Hospital (LPCH), Stanford, California, United States

Brief Summary

The primary purpose of this study is to test whether GD2-CAR T cells can be successfully made from immune cells collected from children and young adults with H3K27M-mutant diffuse intrinsic pontine glioma (DIPG) or spinal H3K27M-mutant diffuse midline glioma (DMG). H3K27Mmutant testing will occur as part of standard of care prior to enrollment.