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About Bolder Science

Our mission is to provide healthcare professionals with unbiased clinical research information, easily.

Currently, you can access the following clinical trials being conducted worldwide:

354,475 studies
in
216 countries
Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 12/02/2020.
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Drug Interventions

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Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 12/02/2020.
Displaying: 186 trials in your specialties ()
View trials across your selected specialties

Fluorine F 18 Fluorodopa-Labeled PET Scan in Planning Surgery and Radiation Therapy in Treating Patients With Newly Diagnosed High- or Low-Grade Malignant Glioma

  • Status
    Active, not recruiting
  • Phase
    Early Phase 1
  • Condition
    Adult Anaplastic Ependymoma, Adult Anaplastic Oligodendroglioma, ...
View Full Trial
INTERVENTION

Procedure: biopsy, Procedure: computed tomography, Procedure: therapeutic conventional surgery, Radiation: radiation therapy treatment planning/simulation, Radiation: radiation therapy, Procedure: magnetic resonance imaging, Procedure: positron emission tomography, Drug: fluorine F 18 fluorodopa

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Mayo Clinic, Rochester, Minnesota, United States

Brief Summary

RATIONALE: New imaging procedures, such as fluorine F 18 fluorodopa-labeled PET scan, may help in guiding surgery and radiation therapy and allow doctors to plan better treatment. PURPOSE: This clinical trial studies fluorine F 18 fluorodopa-labeled PET scan in planning surgery and radiation therapy in treating patients with newly diagnosed high- or low-grade malignant glioma

To Investigate the Absorption, Metabolism, Excretion, Absolute Bioavailability, and Immunogenicity of GX-I7 in Healthy Volunteers

  • Status
    Active, not recruiting
  • Phase
    Early Phase 1
  • Condition
    Leukopenia
View Full Trial
INTERVENTION

Drug: GX-I7 or [14C] GX-I7

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Seoul National University Hospital Clinical Trial Center, Seoul, Korea, Republic of

Brief Summary

A Phase 1, open-labeled, single-dose, one-sequence, one-period, 3-part study to investigate the absorption, metabolism, excretion, absolute bioavailability, and immunogenicity of GX-I7 in healthy volunteers

Dobutamine on the Cardiac Conduction System

  • Status
    Active, not recruiting
  • Phase
    Early Phase 1
  • Condition
    Arrhythmias, Cardiac
View Full Trial
INTERVENTION

Drug: Dobutamine

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Long Island Jewish Hospital, New Hyde Park, New York, United States

Brief Summary

Our hypothesis is that Dobutamine will act in a similar fashion to Isoproterenol with respect to cardiac conduction. Our goal is to study the effects of Dobutamine on cardiac conduction and refractoriness during an Electrophysiology study (EPS). At the end of most EPS Isoproterenol is commonly administered in an effort to change the conduction properties of the heart. In our practice we have been using Dobutamine for this purpose for many years. Dobutamine has never been rigorously studied for this indication however. We designed this study to systematically study the effect of various doses of Dobutamine on the parameters of cardiac conduction and refractoriness that are commonly measured during an EPS. We are specifically looking to compare the effect that Dobutamine has on the sinus node with the effect it has on the atrioventricular node. Patients undergoing an EPS at Long Island Jewish Hospital will be recruited and consented. Measurements of various conduction parameters will be taken at baseline as is standard protocol for an EPS. Dobutamine will then be administered at doses of 5mcg/kg/min, 10mcg/kg/min, 15mcg/kg/min and 20mcg/kg/min. At each of these dosages the same conduction parameters will be measured. A comparison will then be made between the conduction parameters at baseline and when the Dobutamine is administered.

COVID-19 Convalescent Plasma

  • Status
    Active, not recruiting
  • Phase
    Early Phase 1
  • Condition
    Coronavirus
View Full Trial
INTERVENTION

Biological: anti-SARS-CoV-2 convalescent plasma

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

University of Chicago Medicine, Chicago, Illinois, United States

Brief Summary

The purpose of this study is to assess the feasibility of delivering anti-SARS-CoV-2 convalescent plasma to hospitalized patients with severe or life-threatening COVID-19. Beyond supportive care, there are currently no proven treatment options for coronavirus disease (COVID-19), the infection caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Human convalescent plasma is an option for treatment of COVID-19 and could be rapidly available when there are sufficient numbers of people who have recovered and can donate high titer neutralizing immunoglobulin-containing plasma. Hypothesis: Collecting and administering convalescent plasma requires a level of logistical coordination that is not available in all centers. Objective: To establish feasibility for a hospital-based integrated system to collect and administer convalescent plasma to patients with severe or life-threatening COVID-19.

Nivolumab With or Without Bevacizumab or Ipilimumab Before Surgery in Treating Patients With Metastatic Kidney Cancer That Can Be Removed by Surgery

  • Status
    Active, not recruiting
  • Phase
    Early Phase 1
  • Condition
    Clear Cell Renal Cell Carcinoma, Metastatic Kidney Carcinoma, Sta...
View Full Trial
INTERVENTION

Biological: Bevacizumab, Procedure: Biopsy, Biological: Ipilimumab, Other: Laboratory Biomarker Analysis, Procedure: Metastasectomy, Biological: Nivolumab, Procedure: Therapeutic Conventional Surgery

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

M D Anderson Cancer Center, Houston, Texas, United States

Brief Summary

This randomized pilot early phase I trial studies the side effects and how well nivolumab alone works compared to nivolumab with bevacizumab or ipilimumab before surgery in treating patients with kidney cancer, also referred to as renal cell cancer, that has spread to another place in body and can be removed by surgery. Immunotherapy with monoclonal antibodies, such as nivolumab, bevacizumab, and ipilimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.

Modafinil and Cognitive Function in POTS

  • Status
    Active, not recruiting
  • Phase
    Early Phase 1
  • Condition
    Postural Tachycardia Syndrome
View Full Trial
INTERVENTION

Drug: Placebo, Drug: Modafinil, Drug: Propranolol

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Vanderbilt University, Nashville, Tennessee, United States

Brief Summary

A common complaint among patients with Postural Tachycardia Syndrome (POTS) is "brain fog" or difficulty concentrating. This problem is poorly understood. The purpose of this study is to better understand the cognitive dysfunction associated POTS, and to determine optimal treatment strategies for this condition. In this study, the investigators will test the hypothesis that acute administration of the psychostimulant drug modafinil can improve seated measures of cognitive function in patients with POTS.

Screening Inhaled Allergen Challenge for Dermatophagoides Farinae

  • Status
    Active, not recruiting
  • Phase
    Early Phase 1
  • Condition
    Asthma
View Full Trial
INTERVENTION

Biological: Der f

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

UNC Center for Environmental Medicine, Asthma and Lung Biology, Chapel Hill, North Carolina, United States

Brief Summary

This study is designed to identify Dermatophagoides farinae, or Der f, sensitive asthmatics who demonstrate a late phase asthmatic response after Der f inhalation. These subjects may be invited to participate in a planned future study investigating novel asthma treatments.

Non Invasive Oral Cancer Screening Among HIV Infected Individuals

  • Status
    Active, not recruiting
  • Phase
    Early Phase 1
  • Condition
    Malignant Neoplasms of Mesothelial and Soft Tissue, Human Immunod...
View Full Trial
INTERVENTION

Behavioral: Screening Interview, Device: Carbon Monoxide Test, Behavioral: Self-Help Materials, Procedure: Visual Oral Screening Examination, Procedure: Direct Fluorescent Oral Visualization Examination, Procedure: Oral Biopsy

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Bering Omega/Houston Area Community Services, Houston, Texas, United States

Brief Summary

The goal of this clinical research study is to learn how a new method for performing oral (mouth) exams can help doctors check for suspicious lesions (called premalignant and malignant oral lesions [PMOL]) in the mouth of HIV-infected smokers.

Early and Adequate Protein Feeding Post-Traumatic Injury

  • Status
    Active, not recruiting
  • Phase
    Early Phase 1
  • Condition
    Protein Feeding in Post-traumatic Injury Patients
View Full Trial
INTERVENTION

Drug: Routine Nutritional Support plus supplemental IV amino acids, Other: Routine Nutritional Support

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Boston Medical Center, Boston, Massachusetts, United States

Brief Summary

A randomized, parallel-group, pilot study comparing the effect of the early addition of intravenous protein to enteral feeding as tolerated versus enteral feedings as tolerated alone immediately post traumatic injury. Primary: To determine that early and adequate nutritional support will improve protein economy in the first week post -injury as measured by nitrogen balance. We hypothesize that an improvement in nitrogen balance with early maximized protein intake will support the production of acute phase proteins, major antioxidants and the inflammatory response. Secondary: Through the use of mass spectrometry (MS) and nuclear magnetic resonance (NMR) technologies we will determine that our plan for early and adequate nutritional support with adequate protein from day one post injury will alter the metabolomics profile when compared to routine nutritional support. Tertiary: For Specific Aim 3 we will measure several pro- and anti-inflammatory cytokines and soluble proteins.

Surgical Resection and Intraoperative Cesium-131 Brachytherapy for Head and Neck Cancer

  • Status
    Active, not recruiting
  • Phase
    Early Phase 1
  • Condition
    Recurrent Head and Neck Carcinoma
View Full Trial
INTERVENTION

Radiation: Brachytherapy, Drug: Cesium-131, Procedure: Conventional surgery

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania, United States

Brief Summary

This pilot clinical trial studies cesium Cs 131 brachytherapy in treating patients with head and neck cancer that has come back (recurrent) and can be removed by surgery. Brachytherapy, also known as internal radiation therapy, uses radioactive material placed directly into or near a tumor to kill tumor cells. Radioactive drugs, such as cesium Cs 131, may carry radiation directly to tumor cells and not harm normal cells. Permanently implanting cesium Cs 131 into the wound bed after surgery may help treat microscopic cancer cells that may be in the tissue after surgical removal of the tumor.