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At Bolder Science, we want your clinical trial search experience to be the best it can be. Complete the following prompts to easily find the trials you are interested in and see trials recruiting near you. You can adjust these selections in your dashboard after creating your account.

Condition Categories

Condition categories are pulled directly from ClinicalTrials.gov. Choose 1 or more condition categories that you are interested in:

Clinical Trials of Interest

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Propranolol Versus Propranolol and Clonidine in Sympathetic Hyperactivity After Moderate Traumatic Brain Injury

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Traumatic Brain Injury
    Traumatic Brain Injury
  • Phase Early Phase 1
    Early Phase 1
INTERVENTION

Drug: Propranolol

Eligibility
  • Ages: 18 to 60 Years (Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: No
INTERVENTION

Drug: Propranolol

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Faculty Of Medicine, Minya, Egypt

Brief Summary

evaluation of the effect of Propranolol versus propranolol and clonidine on decreasing sympathetic hyperactivity after moderate traumatic brain injury

Black Raspberry Nectar for the Prevention of Lung Cancer, BE WELL Study

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Lung Carcinoma, Tobacco-Related Carcinoma
    Lung Carcinoma, Tobacco-Related Carcinoma
  • Phase Early Phase 1
    Early Phase 1
INTERVENTION

Procedure: Biospecimen Collection, Dietary Supplement: Nutritional Supplementation, Drug: Placebo Administration, Other: Questionnaire Administration

Eligibility
  • Ages: 55 to 77 Years (Adult, Older Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: Yes
INTERVENTION

Procedure: Biospecimen Collection, Dietary Supplement: Nutritional Supplementation, Drug: Placebo Administration, Other: Questionnaire Administration

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Brief Summary

This trial studies how well black raspberry nectar works in changing the gut microbiome and in reducing inflammatory processes that may lead to lung cancer. Studying the effects of black raspberry beverage on inflammation may help doctors find strategies to reduce the risk of developing lung cancer.

Quadratus Lumborum Type 2 as Chronic Hip Pain Treatment

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Hip Arthropathy, Chronic Hip Pain, Ultrasound Therapy; Complications
    Hip Arthropathy, Chronic Hip Pain, Ultrasound Therapy; Complications
  • Phase Early Phase 1
    Early Phase 1
INTERVENTION

Drug: levobupivacaine, Device: ultrasound device

Eligibility
  • Ages: 18 to 85 Years (Adult, Older Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: No
INTERVENTION

Drug: levobupivacaine, Device: ultrasound device

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

María Teresa Fernandez, Valladolid, Castilla Y León, Spain

Brief Summary

The main objective of the study is to assess whether the performance of type 2 quadratus lumborum block produces an improvement in the quality of life of the patient with osteoarthritis of the hip.

Modafinil and Cognitive Function in POTS

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Postural Tachycardia Syndrome
    Postural Tachycardia Syndrome
  • Phase Early Phase 1
    Early Phase 1
INTERVENTION

Drug: Placebo, Drug: Modafinil, Drug: Propranolol

Eligibility
  • Ages: 18 to 60 Years (Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: No
INTERVENTION

Drug: Placebo, Drug: Modafinil, Drug: Propranolol

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Vanderbilt University, Nashville, Tennessee, United States

Brief Summary

A common complaint among patients with Postural Tachycardia Syndrome (POTS) is "brain fog" or difficulty concentrating. This problem is poorly understood. The purpose of this study is to better understand the cognitive dysfunction associated POTS, and to determine optimal treatment strategies for this condition. In this study, the investigators will test the hypothesis that acute administration of the psychostimulant drug modafinil can improve seated measures of cognitive function in patients with POTS.

Dobutamine on the Cardiac Conduction System

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Arrhythmias, Cardiac
    Arrhythmias, Cardiac
  • Phase Early Phase 1
    Early Phase 1
INTERVENTION

Drug: Dobutamine

Eligibility
  • Ages: 18 to 80 Years (Adult, Older Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: Yes
INTERVENTION

Drug: Dobutamine

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Long Island Jewish Hospital, New Hyde Park, New York, United States

Brief Summary

Our hypothesis is that Dobutamine will act in a similar fashion to Isoproterenol with respect to cardiac conduction. Our goal is to study the effects of Dobutamine on cardiac conduction and refractoriness during an Electrophysiology study (EPS). At the end of most EPS Isoproterenol is commonly administered in an effort to change the conduction properties of the heart. In our practice we have been using Dobutamine for this purpose for many years. Dobutamine has never been rigorously studied for this indication however. We designed this study to systematically study the effect of various doses of Dobutamine on the parameters of cardiac conduction and refractoriness that are commonly measured during an EPS. We are specifically looking to compare the effect that Dobutamine has on the sinus node with the effect it has on the atrioventricular node. Patients undergoing an EPS at Long Island Jewish Hospital will be recruited and consented. Measurements of various conduction parameters will be taken at baseline as is standard protocol for an EPS. Dobutamine will then be administered at doses of 5mcg/kg/min, 10mcg/kg/min, 15mcg/kg/min and 20mcg/kg/min. At each of these dosages the same conduction parameters will be measured. A comparison will then be made between the conduction parameters at baseline and when the Dobutamine is administered.

To Investigate the Absorption, Metabolism, Excretion, Absolute Bioavailability, and Immunogenicity of GX-I7 in Healthy Volunteers

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Leukopenia
    Leukopenia
  • Phase Early Phase 1
    Early Phase 1
INTERVENTION

Drug: GX-I7 or [14C] GX-I7

Eligibility
  • Ages: 19 to 45 Years (Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: Yes
INTERVENTION

Drug: GX-I7 or [14C] GX-I7

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Seoul National University Hospital Clinical Trial Center, Seoul, Korea, Republic of

Brief Summary

A Phase 1, open-labeled, single-dose, one-sequence, one-period, 3-part study to investigate the absorption, metabolism, excretion, absolute bioavailability, and immunogenicity of GX-I7 in healthy volunteers

A Phase 1 Study to Evaluate the Safety, Tolerability, PK and PD of SLN124 in Healthy Volunteers

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Healthy Volunteers
    Healthy Volunteers
  • Phase Early Phase 1
    Early Phase 1
INTERVENTION

Drug: SLN124, Drug: Placebo

Eligibility
  • Ages: 18 to 55 Years (Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: Yes
INTERVENTION

Drug: SLN124, Drug: Placebo

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Hammersmith Medicines Research, London, United Kingdom

Brief Summary

This study will evaluate the safety and tolerability of SLN124 in healthy volunteers.

Study to Evaluate the Safety of Combining Two Radionuclide Therapies to Treat Mid-gut Neuroendocrine Tumors

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Neuroendocrine Tumor Gastrointestinal, Hormone-Secreting, Neuroen...
    Neuroendocrine Tumor Gastrointestinal, Hormone-Secreting, Neuroen...
  • Phase Early Phase 1
    Early Phase 1
INTERVENTION

Drug: 90Y-DOTA-3-Tyr-Octreotide, Drug: 131I-MIBG

Eligibility
  • Ages: 18 to 80 Years (Adult, Older Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: No
INTERVENTION

Drug: 90Y-DOTA-3-Tyr-Octreotide, Drug: 131I-MIBG

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Holden Comprehensive Cancer Center, Iowa City, Iowa, United States

Brief Summary

This study is designed to identify the best tolerated doses of [131]Iodine-MIBG and [90]Yttrium-DOTATOC when co-administered to treat midgut neuroendocrine tumors. These drugs (131I-MIBG, 90Y-DOTATOC) are radioactive drugs, known as radionuclide therapy. Currently, the safest and best tolerated doses of these drugs (when combined together) is unknown.

Adrenergic System in Islet Transplantation

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Islet Cell Transplantation, Type1diabetes, Hypoglycemia Unawarene...
    Islet Cell Transplantation, Type1diabetes, Hypoglycemia Unawarene...
  • Phase Early Phase 1
    Early Phase 1
INTERVENTION

Drug: Phentolamine, Drug: Propranolol, Drug: Placebo

Eligibility
  • Ages: 21 to 65 Years (Adult, Older Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: No
INTERVENTION

Drug: Phentolamine, Drug: Propranolol, Drug: Placebo

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

University of Pennsylvania - Institute for Diabetes, Obesity and Metabolism, Philadelphia, Pennsylvania, United States

Brief Summary

To determine the effect of sympathetic neural and hormonal (epinephrine) input on islet cell hormonal responses to insulin-induced hypoglycemia in type 1 diabetic recipients of intrahepatic islet transplantation. We hypothesize that α-adrenergic (neural) blockage will abolish insulin-mediated suppression of C-peptide, attenuating α-cell glucagon secretion during hypoglycemia, and that β-adrenergic (hormonal) blockage will have no effect. Glucose counterregulatory responses will be measured during hyperinsulinemic euglycemic-hypoglycemic clamps on three occasions with randomized, double-blind administration of the α-adrenergic blocker phentolamine, the β-adrenergic blocker propranolol, or placebo. The demonstration of neural rather than hormonal regulation of the transplanted islet cell response to hypoglycemia is critical for understanding the mechanism for protection from hypoglycemia afforded by intrahepatically transplanted.

Surgical Resection and Intraoperative Cesium-131 Brachytherapy for Head and Neck Cancer

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Recurrent Head and Neck Carcinoma
    Recurrent Head and Neck Carcinoma
  • Phase Early Phase 1
    Early Phase 1
INTERVENTION

Radiation: Brachytherapy, Drug: Cesium-131, Procedure: Conventional surgery

Eligibility
  • Ages: 18 to 90 Years (Adult, Older Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: No
INTERVENTION

Radiation: Brachytherapy, Drug: Cesium-131, Procedure: Conventional surgery

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia, Pennsylvania, United States

Brief Summary

This pilot clinical trial studies cesium Cs 131 brachytherapy in treating patients with head and neck cancer that has come back (recurrent) and can be removed by surgery. Brachytherapy, also known as internal radiation therapy, uses radioactive material placed directly into or near a tumor to kill tumor cells. Radioactive drugs, such as cesium Cs 131, may carry radiation directly to tumor cells and not harm normal cells. Permanently implanting cesium Cs 131 into the wound bed after surgery may help treat microscopic cancer cells that may be in the tissue after surgical removal of the tumor.