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At Bolder Science, we want your clinical trial search experience to be the best it can be. Complete the following prompts to easily find the trials you are interested in and see trials recruiting near you. You can adjust these selections in your dashboard after creating your account.

Condition Categories

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Clinical Trials of Interest

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Laser Etching Effect on Application Mode of Universal Adhesive

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Healthy Participant
    Healthy Participant
  • Phase N/A
    N/A
INTERVENTION

Procedure: Self-etch mode Clearfil Universal Bond Quick (Kuraray, Japan) (SE group), Procedure: Total-etch mode with 35% phosphoric acid (K-ETCHANT) (TE-A group), Procedure: Selective-etch mode with 35% phosphoric acid (K-ETCHANT) (SE-A group), Procedure: Total-etch mode with Er, Cr: YSGG laser (Waterlase MD) (TE-L group), Procedure: Selective-etch mode with Er, Cr: YSGG laser (Waterlase MD) (SE-L group).

Eligibility
  • Ages: 18 to 75 Years (Adult, Older Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: Yes
INTERVENTION

Procedure: Self-etch mode Clearfil Universal Bond Quick (Kuraray, Japan) (SE group), Procedure: Total-etch mode with 35% phosphoric acid (K-ETCHANT) (TE-A group), Procedure: Selective-etch mode with 35% phosphoric acid (K-ETCHANT) (SE-A group), Procedure: Total-etch mode with Er, Cr: YSGG laser (Waterlase MD) (TE-L group), Procedure: Selective-etch mode with Er, Cr: YSGG laser (Waterlase MD) (SE-L group).

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Hacettepe University Faculty of Dentistry, Ankara, Turkey

Brief Summary

To evaluate the clinical performance of the restorations by applying the universal adhesive in different modes under the influence of different surface treatments, with Erbium Chromium:Yttrium-Scandium-Gallium-Garnet (Er,Cr:YSGG) laser and acid etching in non-carious cervical lesions.

To Evaluate the Efficacy and Safety of NMN as an Anti-ageing Supplement in Middle Aged and Older (40-65 Years) Adults

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Aging
    Aging
  • Phase N/A
    N/A
INTERVENTION

Drug: Nicotinamide Mononucleotide, Other: Placebo

Eligibility
  • Ages: 40 to 65 Years (Adult, Older Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: Yes
INTERVENTION

Drug: Nicotinamide Mononucleotide, Other: Placebo

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Swasthiya Clinic and Research Center, Pune, Maharashtra, India

Brief Summary

It will be a two-part study. Part I will be six arms; randomized, double blind, parallel design, placebo-controlled dose ranging study. Part II will be open-label single dose study at the highest dose. A total of 90 Subjects (Part 1 & Part 2) will be enrolled in the study. The Part 1 group subjects (80 Subjects) shall be randomly distributed between the six arms, i.e. 20 Subjects each in IP arms, and 7, 7 and 6 subjects in corresponding placebo arms. All Part 2 Group subjects (10 Subjects) will be assigned into the cluster where all receive the maximum NMN dose (900 mg)

Conectar Jugando Online: Board Games to Improve Executive Function in School-age Children (CJ-Online)

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Cognitive Change, Child Development
    Cognitive Change, Child Development
  • Phase N/A
    N/A
INTERVENTION

Behavioral: Conectar Jugando Online Program

Eligibility
  • Ages: 6 to 12 Years (Child)
  • Sexes: All
  • Accepts Healthy Volunteers: Yes
INTERVENTION

Behavioral: Conectar Jugando Online Program

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Faculty of Education, Psychology and Social Work; University of Lleida, Lleida, Spain

Brief Summary

Good development of executive functions at school has been related to a better adaptation of children in different areas of their daily life and, especially, with adequate academic performance. Taking into account the importance of play in childhood, some interventions aimed at training these cognitive processes have been based on the use of playful elements, such as modern board games. Although it is still an unexplored field of research, some studies with older elementary school children and with ADHD children have found significant improvements in executive functions after training that had the board game as a key intervention element. However, we still do not have studies that have explored the possible cognitive benefits of its use throughout the primary stage with the general population. For this reason, the main objective of this study is to test the effectiveness of a cognitive training program based on modern board games in primary education children (6 to 12 years old).

Wear-Time Trial for Self-Fitting Hearing Aid

  • Status Recruiting
    Recruiting
  • Condition Hearing Loss, Sensorineural
    Hearing Loss, Sensorineural
  • Phase N/A
    N/A
INTERVENTION

Device: Hearing aids

Eligibility
  • Ages: 18 to 75 Years (Adult, Older Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: Yes
INTERVENTION

Device: Hearing aids

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Northwestern University, Evanston, Illinois, United States

Brief Summary

This document describes a clinical validation study for a double-blind repeated-measures comparative study of the GN self-fitting method to a validated audiology-best-practices method when fitting the GN Self-fitting Hearing Aid, a device intended for persons aged 18-75 years old who have mild-to-moderate hearing loss. A crossover wear-time field trial will be conducted. The focus of the study is on the validity of the self-fitting process used to select appropriate frequency-gain characteristics for the GN Self-fitting Hearing Aid, and the safety and effectiveness of the device.

Improving Wellbeing Through the Brain-Gut-Microbiota Axis

  • Status Recruiting
    Recruiting
  • Condition Healthy Lifestyle
    Healthy Lifestyle
  • Phase N/A
    N/A
INTERVENTION

Behavioral: Gastric interoceptive training, Behavioral: Gastric interoceptive control task

Eligibility
  • Ages: 18 to 65 Years (Adult, Older Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: Yes
INTERVENTION

Behavioral: Gastric interoceptive training, Behavioral: Gastric interoceptive control task

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Pontificia Universidad Católica de Chile, Santiago, Region Metropolitana, Chile

Brief Summary

Well-being is a state defined as the optimal psychological functioning and the experience associated with it, integrating physical and subjective factors. It has been suggested that the bidirectional interaction between the brain and the rest of the body is fundamental in the regulation of wellbeing levels. In particular, the gastrointestinal system (modulated by the microbiota) sends information that is integrated by the brain, affecting its functioning and mental processes. However, the mechanism of such communication is still unknown. The aim of this proposal is to study the different ways in which psychological processes can influence gut signals and vice versa, and how this relationship might be trained or modified in order to improve wellbeing.

Safety and Efficacy of TaurusOne® Transcatheter Aortic Valve System in Patients With Severe Calcific Aortic Stenosis

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Aortic Stenosis
    Aortic Stenosis
  • Phase N/A
    N/A
INTERVENTION

Device: TaurusOne® transcatheter aortic valve replacement system

Eligibility
  • Ages: 70 Years and older (Older Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: No
INTERVENTION

Device: TaurusOne® transcatheter aortic valve replacement system

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Peiga Medical Technology (Suzhou) Co., Ltd, Suzhou, Jiangsu, China

Brief Summary

To observe and evaluate the safety and efficacy of TaurusOne® transcatheter aortic valve system in patients with severe calcific aortic stenosis through a prospective, multicenter clinical trial using objective performance criteria.

Virtual Reality Meditation for Fatigue

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Fatigue, Rheumatoid Arthritis
    Fatigue, Rheumatoid Arthritis
  • Phase N/A
    N/A
INTERVENTION

Device: Virtual Reality Meditation

Eligibility
  • Ages: 18 Years and older (Adult, Older Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: No
INTERVENTION

Device: Virtual Reality Meditation

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Rheumatology Clinic at UW Medical Center - Roosevelt, Seattle, Washington, United States

Brief Summary

This study will examine the feasibility and acceptability of using virtual reality (VR) meditation to manage fatigue in outpatients with rheumatoid arthritis (RA). The specific aims of this feasibility study include: 1) examining the feasibility of implementing VR meditation as an adjunct for managing fatigue in outpatients with rheumatoid arthritis; 2) determine the acceptability of using VR-delivered meditation training for fatigue management in outpatients with rheumatoid arthritis; and 3) is to explore outpatient's experience of using VR-delivered meditation to manage fatigue.

Risk Factors for Pediatric Emergence Agitation and Analysis of Serum or Urine Metabonomics in Children With Agitation

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Emergence Agitation, Pain, Metabolomics
    Emergence Agitation, Pain, Metabolomics
  • Phase N/A
    N/A
INTERVENTION

Not provided

Eligibility
  • Ages: 3 to 12 Years (Child)
  • Sexes: All
  • Accepts Healthy Volunteers: No
INTERVENTION

Not provided

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Shanghai No.9 People's Hospital, Shanghai, China

Brief Summary

It is known that some factors are associated with emergence agitation(EA), and investigators are still unable to predict accurately those who undergoing maxillofacial surgery are at great risks.This study intend to identify the risk factors for EA and to explore the mechanism of EA , which is helpful for early prediction, prevention and treatment in children.

A Study to Compare the 12-month Spatz3 Adjustable Balloon With a 6-month Non Adjustable Balloon

  • Status Enrolling by invitation
    Enrolling by invitation
  • Condition Obesity
    Obesity
  • Phase N/A
    N/A
INTERVENTION

Device: Gastric Balloon

Eligibility
  • Ages: 18 to 65 Years (Adult, Older Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: No
INTERVENTION

Device: Gastric Balloon

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Asclepiades - interna a gastroenterologie, s.r.o., Havířov, Czechia

Brief Summary

The purpose of this study is to compare a 12-month adjustable balloon over a 6-month non-adjustable balloon with 6-month dietician follow-up. The endpoint is %TBL at 12 months.

FOODLIT-PRO: Improving Food Literacy and Food Sustainability Amidst the COVID-19 Pandemic

  • Status Active, not recruiting
    Active, not recruiting
  • Condition Food Literacy, Food Habits, Behavior and Behavior Mechanisms, Eat...
    Food Literacy, Food Habits, Behavior and Behavior Mechanisms, Eat...
  • Phase N/A
    N/A
INTERVENTION

Behavioral: Experimental Group, Behavioral: Comparison Group

Eligibility
  • Ages: 18 Years and older (Adult, Older Adult)
  • Sexes: All
  • Accepts Healthy Volunteers: Yes
INTERVENTION

Behavioral: Experimental Group, Behavioral: Comparison Group

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

ISPA - Instituto Universitário, Lisboa, Portugal

Brief Summary

Given that healthy food-related habits are protective of both malnutrition and multiple noncommunicable diseases (including diabetes, heart disease, and cancer), and acknowledging that poor diets constitute a greater risk to mortality, it is essential to improve individuals' food-related knowledge, skills, and behaviours. Furthermore, the current public health context caused by the COVID-19 pandemic has reinforced the need for an adequate diet as a protective factor for one's global health. In the ambit of the FOODLIT-PRO: Food Literacy Project (ref. SFRH/BD/128528/2017), a digital intervention to promote food literacy - that is, food-related knowledge, competencies, and behaviours - encompassing behavioural change strategies and psychological determinants (such as intention, planning, and self-efficacy) was developed. With the online deliver of personalised evidence-based materials concerning food literacy, adult participants receive weekly challenges that promote their food-related knowledge (e.g., recognising food's origin and seasonality), competencies (e.g., as cooking and planning skills), and behaviours (e.g., tracking food intake, interpret nutritional labels). Matched with tailored behavioural change strategies (experimental group), both food literacy content and psychological aspects that relate to health behaviour are assessed weekly in order to evaluate the intervention's efficacy. Follow-ups at 3-, 6- and 9-months post intervention will be assessed.