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About Bolder Science

Our mission is to provide healthcare professionals with unbiased clinical research information, easily.

Currently, you can access the following clinical trials being conducted worldwide:

354,475 studies
in
216 countries
Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 12/02/2020.
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Drug Interventions

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Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 12/02/2020.
Displaying: 714 trials in your specialties ()
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Intravenous Paracetamol, Dexketoprofen and Ibuprofen in the Treatment of Acute Migraine Attack Headache

  • Status
    Active, not recruiting
  • Phase
    Phase 4
  • Condition
    Headache, Migraine
View Full Trial
INTERVENTION

Drug: Paracetamol, Drug: Dexketoprofen, Drug: Ibuprofen

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Pamukkale University, Denizli, Turkey

Brief Summary

- Currently, paracetamol and nonsteroidal antiinflammatory drugs are widely used by emergency physicians in Turkey for the treatment of patients with Acute Migraine Attack Headache - The objective of the study is compare the efficacy of intravenous dexketoprofen,ibuprofen with paracetamol in the treatment of acute Migraine Attack Headache

Effects of Switching From Racemic Methadone to R-methadone on QTc Intervals

  • Status
    Active, not recruiting
  • Phase
    Phase 4
  • Condition
    Adverse Drug Effect, Drug Effect, Heart Arrhythmia
View Full Trial
INTERVENTION

Drug: Same individuals treated with racemic methadone and switched to levomethadone (R-methadone)

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Department of Pharmacology , Oslo University Hospital, Oslo, Norway

Brief Summary

Effects of switching from racemic methadone to R-methadone on serum methadone concentrations and QTc intervals

Safety and Efficacy of the Sore Throat Lozenges to Treat Acute Sore Throats

  • Status
    Active, not recruiting
  • Phase
    Phase 4
  • Condition
    Tonsillopharyngitis, Respiratory Tract Infection Viral
View Full Trial
INTERVENTION

Drug: A. Vogels Sore Throat lozenges

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Diagnostics and Consultation Center Convex EOOD, Sofia, Bulgaria

Brief Summary

Aim of this study is to investigate safety and efficacy of A. Vogel Sore throat lozenges for the treatment of of acute sore throats

Effect of Amlodipine Versus Bisoprolol on Hypertensive Patients With End-stage Renal Disease on Maintenance Hemodialysis.

  • Status
    Active, not recruiting
  • Phase
    Phase 4
  • Condition
    Hypertension, Renal
View Full Trial
INTERVENTION

Drug: Bisoprolol Fumarate 5-10 mg, Drug: Amlodipine 5-10 mg

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

El Mowassat University hospital, Alexandria, Egypt

Brief Summary

Hypertension is highly prevalent in hemodialysis (HD) patients and leads to increased morbidity and mortality due to cardiovascular disease(CVD). Left ventricular hypertrophy (LVH) is both a manifestation of hypertension caused end-organ damage and an independent risk factor for CVD. Evidence shows that Beta-blockers, especially of low dialyzability decrease risk of CVD and mortality. Calcium channel blockers (CCBs) were also shown to effectively control BP in the volume expanded state and reduce cardiovascular disease risk. Asymmetric dimethyl arginine (ADMA) is a uremic toxin that decreases NO synthesis and is correlated to LVH, carotid intimal thickness (CIT), CVD, and mortality. Amlodipine is shown in one study to significantly reduce ADMA level in HD patients. The purpose of this study is to determine the effect of calcium channel blocker Amlodipine compared to Beta-blocker Bisoprolol on regression of LVH, reduction of ADMA plasma level and on BP control among hypertensive patients on HD.

Evaluation of Complication Rates Using Filter vs. Centrifuge and Heparin vs. Citrate Anticoagulation

  • Status
    Active, not recruiting
  • Phase
    Phase 4
  • Condition
    Therapeutic Plasma Exchange, Anticoagulant Therapy
View Full Trial
INTERVENTION

Device: Active Comparator: centrifuge TPE with citrate, Device: Active Comparator: Filter TPE with heparin, Drug: Active comparator: Filter TPE with citrate

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

University of Alabama, Birmingham, Alabama, United States

Brief Summary

Despite its growing use across the world, and similar efficacy, filter-based therapeutic plasma exchange (TPE) continues to be used less often that centrifuge-based TPE. One of the reasons is that the patient and circuit complications of centrifuge-based TPE are familiar to the clinical team. There is little data on the patient and circuit complications of filter-based TPE (using the Prismaflex). Furthermore, there is a reluctance to use filter-based TPE because historically, most TPE programs have used citrate-regional anticoagulation, and there is a large gap in knowledge in the use of citrate regional anti-coagulation when using filter-based TPE.

Comparative Study for Treatment of Alopecia Areata Using Carboxytherapy and Intralesional Steroids

  • Status
    Active, not recruiting
  • Phase
    Phase 4
  • Condition
    Alopecia Areata
View Full Trial
INTERVENTION

Device: Carboxytherapy, Drug: Intralesional Steroid Injection

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Kasr ElAiny Hospital, Cairo university, Cairo, El Manial, Egypt

Brief Summary

Patients with three lesions of alopecia areata are randomly recruited in this study. Each lesion is randomized in to receiving either carboxytherapy in one lesion, intralesional steroids in another lesion and combination of both in the third lesion. Treatment period is 3 months followed by a follow-up period of 2 months.

Phthalates Exposure in Type 2 Diabetic Patients and Diuretic Therapy

  • Status
    Active, not recruiting
  • Phase
    Phase 4
  • Condition
    Renal Function Disorder, Glucose Metabolism Disorders
View Full Trial
INTERVENTION

Drug: Dapagliflozin 10 MG, Drug: Hydrochlorothiazide 12.5mg

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

University of Pisa, Pisa, Italy

Brief Summary

In this open clinical trial, 30 subjects with inadequately controlled T2D and eligible, as per good clinical practice, for therapy with SGLT-2 inhibitor, will be randomized to receive a SGLT-2 inhibitor vs other oral-antidiabetic drugs (OADs) therapy for 3 months. Measures will be performed at baseline, after 2 days, after one month and at the end of the study protocol, as per good clinical practice

TRPV2 Agonists in the Fontan Circulation

  • Status
    Active, not recruiting
  • Phase
    Phase 4
  • Condition
    Fontan
View Full Trial
INTERVENTION

Drug: Probenecid

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Cincinnati Childrens Hospital Medical Center, Cincinnati, Ohio, United States

Brief Summary

There are currently very few proven pharmacologic options available for these patients. The recent discovery of transient receptor potential vanilloid (TRPV) channels, particularly TRPV2 channels, in the cardiovascular system is promising as a potential pathway for pharmacologic intervention for Fontan patients. Probenecid, a drug best known as a treatment for gout or as a penicillin adjunct, acts as a TRPV2 agonist and has recently become the subject of study as a model therapy for the treatment of cardiomyopathy due to its positive inotropic and lusitropic effects. The purpose of this pilot study is to determine if probenecid will improve magnetic resonance (MRI) parameters of systolic and/or diastolic dysfunction as well as associated symptoms in patients with a Fontan circulation. The investigators will quantitatively assess functional improvement with pre- and post-treatment cardiopulmonary exercise testing.

Reducing COVID-19 Related Hospital Admission in Elderly by BCG Vaccination

  • Status
    Active, not recruiting
  • Phase
    Phase 4
  • Condition
    COVID-19
View Full Trial
INTERVENTION

Biological: BCG vaccine, Biological: Placebo

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Radboud University, Nijmegen, Gelderland, Netherlands

Brief Summary

Bacillus Calmette-Guérin (BCG) vaccine not only protects against tuberculosis, but has also been shown to induce protection against various infections with a viral aetiology, leading to significant reductions in morbidity and mortality. We hypothesize that BCG vaccination might be a potent preventive measure against SARS-CoV-2 infection and/or may reduce disease severity in elderly people, who are known to be at increased risk of illness and death from SARS-CoV-2 infection. Therefore, we will in this placebo-controlled adaptive multi-centre randomized controlled trial evaluate the ability of BCG to reduce hospital admission and its efficacy to improve the clinical course of SARS-CoV-2 infection in elderly people((≥ 60 years of age).

Phophate Lowering Trial

  • Status
    Active, not recruiting
  • Phase
    Phase 4
  • Condition
    Chronic Kidney Disease, Cardiovascular Disease
View Full Trial
INTERVENTION

Drug: placebo, Drug: Ascorbic Acid, Drug: Nitroglycerin, Procedure: Flow-mediated dilation measurement, Drug: Lanthanum carbonate, Procedure: Aortic pulse-wave velocity, Procedure: Endothelial cell collection

Eligibility
  • Ages:
  • Sexes: All
  • Accepts Healthy Volunteers:
Locations

Rocky Mountain Regional VA Medical Center, Aurora, CO, Aurora, Colorado, United States

Brief Summary

The proposed research is a randomized-controlled trial to determine the effectiveness of reducing serum phosphorus using a phosphate binder, lanthanum carbonate, for improving the function of arteries in adults with moderate to severe chronic kidney disease (CKD). [COMIRB 13-0328] Additionally, it will determine phosphorus balance among adults with CKD and whether there is a difference in phosphorus balance after three months of treatment with lanthanum carbonate. [COMIRB 15-0384]