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Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 10/30/2020.
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Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 10/30/2020.
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Our Science

    • CC-93269 (Anti-BCMA T-Cell Engager)

    The safety and efficacy of the agents and/or uses under investigation have not been established. There is no guarantee that the agents will receive health authority approval or become commercially available in any country for the uses being investigated.

    Proposed Mechanism of Action

    CC-93269 is an investigational, humanized IgG1-based 2+1 T-cell engager (TCE) designed to bind to B-cell maturation antigen (BCMA) on malignant and non-malignant plasma cells and CD3ε on T cells, thus coupling both cell types.1,2 This simultaneous binding is proposed to result in T-cell activation and cytokine release, followed by cytolytic synapse formation and secretion of cytolytic enzymes.1,2

    `

    CC-93269 by Disease State

    CC-93269 in Multiple Myeloma

    Phase 1
    Relapsed/refractory

    View Trials Investigating CC-93269 in Multiple Myeloma
    View Rationale for Clinical Development

    Rationale for Clinical Development

    BCMA is a promising target for the treatment of multiple myeloma using various investigational modalities, such as a TCE, because it is universally expressed on the surface of malignant and non-malignant plasma cells and is essential for the survival of these cells.1,3,4 Preclinical studies have shown that anti-BCMA TCEs may cross-link T cells with BCMA-expressing cells, including malignant myeloma cells, potentially leading to increased immune antitumor activity via redirected killing of myeloma and healthy plasma cells by autologous T cells.1,2 Preclinical studies are ongoing to optimize, improve, and assess the potential benefits and risks of CC-93269 as a single agent therapy or in combination with other therapies in multiple myeloma.

    View Related Pathways

    T-Cell Engagers
    B-Cell Maturation Antigen (BCMA)

    References

    1. Seckinger A, et al. Cancer Cell. 2017;31:396-410. PMID: 28262554
    2. Vu MD, et al. Blood. 2015;126:2998.
    3. Tai YT, Anderson KC. Immunotherapy. 2015;7:1187-1199. PMID: 26370838
    4. Carpenter RO, et al. Clin Cancer Res. 2013;19:2048-2060. PMID: 23344265