About Bolder Science

Our mission is to provide healthcare professionals with unbiased clinical research information, easily.

Currently, you can access the following clinical trials being conducted worldwide:

379188 studies
220 countries
Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 07/24/2021.
This website is for US healthcare professionals

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At Bolder Science, we want your clinical trial search experience to be the best it can be. Complete the following prompts to easily find the trials you are interested in and see trials recruiting near you. You can adjust these selections in your dashboard after creating your account.

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Our Science

iberdomide (CC-220; CELMoD Agent)

The safety and efficacy of the agents and/or uses under investigation have not been established. There is no guarantee that the agents will receive health authority approval or become commercially available in any country for the uses being investigated.

Proposed Mechanism of Action

Iberdomide (CC-220) is an investigational cereblon E3 ligase modulator (CELMoD agent); CELMoD agents have been shown in preclinical studies to co-opt the protein cereblon (CRBN), resulting in the redirection of specific target proteins for degradation by the ubiquitin proteasome system (UPS).1,2 Iberdomide modulates CRBN such that the transcription factors Ikaros and Aiolos are degraded and led to death of cancer cells and stimulation of immune effector cells such as T cells and natural killer cells in in vitro preclinical models.3-5