- Solid Tumors
- Pipeline Molecules
- Alliance Partners
Our mission is to provide healthcare professionals with unbiased clinical research information, easily.
Currently, you can access the following clinical trials being conducted worldwide:
Proposed Mechanism of Action
Iberdomide (CC-220) is an investigational cereblon E3 ligase modulator (CELMoD agent); CELMoD agents have been shown in preclinical studies to co-opt the protein cereblon (CRBN), resulting in the redirection of specific target proteins for degradation by the ubiquitin proteasome system (UPS).1,2 Iberdomide modulates CRBN such that the transcription factors Ikaros and Aiolos are degraded and led to death of cancer cells and stimulation of immune effector cells such as T cells and natural killer cells in in vitro preclinical models.3-5