The safety and efficacy of the agents and/or uses under investigation have not been established. There is no guarantee that the agents will receive health authority approval or become commercially available in any country for the uses being investigated.
Proposed Mechanism of Action
Ide-cel is an investigational chimeric antigen receptor (CAR) T cell therapy targeting B-cell maturation antigen (BCMA), which is expressed on the surface of normal and malignant plasma cells.1,2 The ide-cel CAR construct includes an anti-BCMA scFv-targeting domain for antigen specificity, a transmembrane domain, CD3-zeta T-cell activation domain, and a 4-1BB domain hypothesized to increase T-cell activation, proliferation, and persistence.1,3-5 Ide-cel CAR T cells are proposed to recognize and bind BCMA on the surface of plasma cells leading to apoptosis.6,7
Ide-cel Proposed Mechanism of Action