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Our mission is to provide healthcare professionals with unbiased clinical research information, easily.

Currently, you can access the following clinical trials being conducted worldwide:

342,868 studies
in
216 countries
Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 08/10/2020.
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Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 08/10/2020.
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Our Science

    • Marizomib (Proteasome Inhibitor)

    The safety and efficacy of the agents and/or uses under investigation have not been established. There is no guarantee that the agents will receive health authority approval or become commercially available in any country for the uses being investigated.

     

    Proposed Mechanism of Action

    Marizomib is a proteasome inhibitor derived from a novel marine-obligate actinomycete that belongs to the β-lactone-γ-lactam superfamily of proteasome inhibitors.1 In in vitro experiments, marizomib has demonstrated irreversible binding to and inhibition of all 3 proteolytic subunits of the human proteasome complex, resulting in inhibition of proteasome activity.2,3

    Celgene acquired this asset from Triphase in 2016. Triphase continues to support marizomib’s development by remaining involved with the ongoing clinical trials.

    Marizomib by Disease State

    Marizomib in Solid Tumors

    Phase 3
    Newly diagnosed glioblastoma

    View Trials Investigating Marizomib in Solid Tumors
    View Rationale for Clinical Development

    Rationale for Clinical Development

    In vitro experiments have revealed that marizomib inhibited proliferation and invasion and induced apoptosis in glioma cells.4 In addition, studies in rats demonstrated distribution of marizomib into the brain, and studies in monkeys demonstrated inhibition of chymotrypsin-like proteasome activity in brain tissues.4

    View Related Pathways

    Proteasome Pathway

    References

    1. Feling RH, et al. Angew Chem Int Ed Engl. 2003;42:355-357. PMID: 12548698
    2. Groll M, et al. J Am Chem Soc. 2006;128:5136-5141. PMID: 16608349
    3. Chao T-H, et al. 100th Annual AACR Meeting [abstract 4539].
    4. Di K, et al. Neuro Oncol. 2016;18:840-848. PMID: 26681765