About Bolder Science

Our mission is to provide healthcare professionals with unbiased clinical research information, easily.

Currently, you can access the following clinical trials being conducted worldwide:

379188 studies
220 countries
Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 07/24/2021.
This website is for US healthcare professionals

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At Bolder Science, we want your clinical trial search experience to be the best it can be. Complete the following prompts to easily find the trials you are interested in and see trials recruiting near you. You can adjust these selections in your dashboard after creating your account.

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Our Science

romidepsin (Histone Deacetylase Inhibitor)

The safety and efficacy of the agents and/or uses under investigation have not been established. There is no guarantee that the agents will receive health authority approval or become commercially available in any country for the uses being investigated.

Proposed Mechanism of Action

The epigenetic modifier romidepsin is a potent class 1 selective histone deacetylase inhibitor.1-2?Altered expression, dysregulation, and mutations of histone deacetylase (HDAC) genes have been implicated in tumor development in cells of various cancers.3,4?In preclinical studies, HDAC inhibitors, such as romidepsin, prevent HDACs from removing acetyl groups, both allowing DNA to remain transcriptionally active (eg, tumor suppressor genes) and maintaining the acetylation of non-histone proteins (eg, genes involved in cell growth and differentiation).1,3,5?The downstream anti-cancer effects of HDAC inhibitors potentially include interference with cell cycle and mitosis, decreased cell motility, decreased angiogenesis, cell differentiation, and cell death.1,3,4,6

Romidepsin Hypothesized Mechanism of Action

Binding of romidepsin to HDACs has been hypothesized to result in various downstream anti-cancer effects, including in lymphoma.