About Bolder Science

Our mission is to provide healthcare professionals with unbiased clinical research information, easily.

Currently, you can access the following clinical trials being conducted worldwide:

351,441 studies
in
216 countries
Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 10/25/2020.
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Clinical Trials of Interest

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Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 10/25/2020.
Our Science
  • Biotherapeutics and Novel Targets

    The safety and efficacy of the agents and/or uses under investigation have not been established. There is no guarantee that the agents will receive health authority approval or become commercially available in any country for the uses being investigated.

     

    The term biotherapeutics refers to agents that are created from biological sources using recombinant DNA technology, such as antibodies and proteins.1 Many biotherapeutics target a specific component or, in some cases, multiple components of disease pathways, including growth factor receptors and proteins that are upstream regulators of these receptors, to control or halt the progression of cancer.1,2 Some biotherapeutics function by triggering an immune response or specifically target cancer stem cells,1,3 and others, called immune antibody drug conjugates, deliver potent payloads directly to a target cell or tissue via the specificity of the antibody component.4 Biotherapies are quickly becoming an important modality in the targeted treatment of cancer.1

    In addition, ongoing research continues to uncover new molecules and mechanisms involved in dysregulated pathways in cancer. Biologic and non-biologic agents targeting various aspects of these pathways are continually in development in hopes of providing treatments for patients with cancer.

    References

    1. National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/bio-therapies-fact-sheet.
    2. Schaefer W, et al. Proc Natl Acad Sci U S A. 2011;108-11187-11192. PMID: 21690412
    3. Chen K, et al. Acta Pharmacologica Sinica. 2013:34:732-740. PMID: 23685952
    4. Zolot RS, et al. Nat Rev Drug Discov. 2013;12:259-260. PMID: 23535930