About Bolder Science

Our mission is to provide healthcare professionals with unbiased clinical research information, easily.

Currently, you can access the following clinical trials being conducted worldwide:

339,504 studies
in
214 countries
Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 06/01/2020.
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Clinical Trials of Interest

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finding clinical trials in which to enroll my patients

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Drug Interventions

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Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 06/01/2020.
Our Science
  • Protein Homeostasis

    The safety and efficacy of the agents and/or uses under investigation have not been established. There is no guarantee that the agents will receive health authority approval or become commercially available in any country for the uses being investigated.

     

    Maintenance of protein homeostasis is a critical function of the cell, and disruptions of this process contribute to the development of numerous diseases, including cancer.1-3 Ubiquitination and degradation of proteins is a key component of protein homeostasis, and proteins involved in this process, including E3 ubiquitin ligases, are increasingly being investigated as therapeutic targets.2,3

    Celgene is developing cancer treatments directed at key biological pathways in protein homeostasis.

    References

    1. Sontag EM, et al. Curr Opin Cell Biol. 2014;26:139-146. PMID: 24463332
    2. García-Santisteban I, et al. Mol Cancer. 2013;12:91. PMID: 23937906
    3. Sévère N, et al. Cell Death Dis. 2013;4:e463. PMID: 23328670
    4. Gandhi AK, et al. Br J Haematol. 2014;164:811-821. PMID: 24328678
    5. Kronke J, et al. Science. 2014;343:301-305. PMID: 24292625
    6. Lu G, et al. Science. 2014;343:305-309. PMID: 24292623