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Our mission is to provide healthcare professionals with unbiased clinical research information, easily.

Currently, you can access the following clinical trials being conducted worldwide:

351,441 studies
in
216 countries
Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 10/30/2020.
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Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 10/30/2020.
  • Proteasome Pathway

    The safety and efficacy of the agents and/or uses under investigation have not been established. There is no guarantee that the agents will receive health authority approval or become commercially available in any country for the uses being investigated.

     

    The ubiquitin proteasome pathway (UPP) plays a central role in cellular homeostasis in the processing and degradation of proteins, including those that regulate cell-cycle progression, apoptosis, and DNA repair.1,2 The 26S proteasome, a key element of the UPP, is formed by the 20S proteolytic core and 19S regulatory particle.1-4 Polyubiquitinated proteins that are destined for degradation by the UPP are recognized by the 19S particle and directed to the 20S core, where proteolytic cleavage is mediated by 3 β subunits: β1 (caspase-like activity), β2 (trypsin-like activity), and β5 (chymotrypsin-like activity).1-3,5

    Inhibition of proteasome activity may result in growth arrest and cell death due to the accumulation of regulatory proteins and the induction of apoptotic signaling within the cell.1,2

    View Related Molecules

    References

    1. Kybuczkova L, et al. J Cell Mol Med. 2014;18:947-961. PMID: 24712303
    2. Crawford LJ, et al. J Cell Commun Signal. 2011;5:101-110. PMID: 21484190
    3. Jager S, et al. J Mol Biol. 1999;291:997-1013. PMID: 10452902
    4. Heinemeyer W, et al. J Biol Chem. 1997;272:25200-25209. PMID: 9312134
    5. Groll M, et al. Nature. 1997;386:463-471. PMID: 9087403