A Placebo-Controlled Study of Oral Ozanimod as Maintenance Therapy for Moderately to Severely Active Crohn's Disease
Clinicaltrials.gov identifier recruitment status First Posted Last update posted
NCT03464097 Recruiting March 13, 2018 July 4, 2022

study description
Brief Summary

This is a study to demonstrate the effect of oral ozanimod as maintenance therapy in participants with moderately to severely active Crohn's Disease.

Condition or Disease: Crohn Disease
Intervention/treatment: Drug: Ozanimod
Other: Placebo
Phase: Phase 3
Detailed Description

N/A


study design
Study Type: Interventional
Estimated Enrollment : 485 participants
Intervention Model : Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: A Placebo-Controlled Study of Oral Ozanimod as Maintenance Therapy for Moderately to Severely Active Crohn's Disease
Actual Study Start Date: June 2018
Estimated Primary Completion Date: June 2024
Estimated Study Completion Date: September 2024

Arms and interventions
Arm Intervention/treatment
Experimental: Ozanimod
Drug: Ozanimod
Specified dose on specified days
Placebo Comparator: Placebo
Other: Placebo
Specified dose on specified days
outcome measures
Primary Outcome Measures: 1. Proportion of participants with a Crohn's Disease Activity Index (CDAI) score of < 150 [ Time Frame: Weekk 52 ]
The Crohn's Disease Activity Index (CDAI) is a composite score that is used to measure the clinical activity of CD
2. Proportion of participants with a Simple Endoscopic Score for Crohn's Disease (SES-CD) score decrease from baseline of ≥ 50% [ Time Frame: Week 52 ]
Secondary Outcome Measures: 1. Proportion of participants with CDAI reduction from baseline of ≥ 100 points or CDAI score of < 150 [ Time Frame: Week 52 ]
2. Proportion of participants with average daily abdominal pain score ≤ 1 point and average daily stoolfrequency ≤ 3 points with abdominal pain and stool frequency no worse than baseline [ Time Frame: Week 52 ]
3. Proportion of participants with a CDAI score < 150 at Week 52, while remaining corticosteroid-free in the prior 12 weeks [ Time Frame: Week 52 ]
4. Proportion of participants with a CDAI score of < 150 in participants with a CDAI score < 150 at pre-randomization [ Time Frame: Week 52 ]
5. Proportion of participants with a CDAI score of < 150 at Week 52 and at ≥ 80% of visits between Week 8 and Week 52, inclusive, in participants with a CDAI score <150 at pre-randomization [ Time Frame: Week 52 ]
6. Proportion of participants with absence of ulcers ≥ 0.5 cm with no segment with any ulcerated surface ≥ 10% at Week 52 [ Time Frame: Week 52 ]
7. Histologic improvement based on differences between ozanimod and placebo in histologic diseaseactivity scores (ie, Global Histologic Disease Activity Score [GHAS] changes) [ Time Frame: Week 52 ]
8. Proportion of participants with average daily abdominal pain score ≤ 1 point, with average daily stool frequency score ≤ 3 points with abdominal pain and stool frequency no worse than baseline and an SES-CD decrease from baseline of ≥ 50% [ Time Frame: Week 52 ]
9. Proportion of participants with CDAI score of < 150 and SES-CD decrease from baseline of ≥ 50% [ Time Frame: Week 52 ]
10. Proportion of participants with average daily abdominal pain score ≤ 1 point, with average daily stoolfrequency score ≤ 3 points with abdominal pain and stool frequency no worse than baseline and an SES-CD ≤ 4 points and a SES-CD decrease ≥2 points [ Time Frame: Week 52 ]
11. Proportion of participants with CDAI reduction from baseline of ≥ 100 points or CDAI score < 150 with SES-CD decrease from baseline of ≥ 50% [ Time Frame: Week 52 ]
12. Proportion of participants with CDAI score < 150 at Week 12 and SES-CD decrease from baseline of ≥50% [ Time Frame: Week 52 ]
13. Proportion of participants with CDAI reduction from baseline of ≥ 70 points [ Time Frame: Week 52 ]
14. Proportion of participants with mucosal healing (SES-CD ≤ 4 points and a SES-CD decrease ≥ 2 points) with histologic improvement by GHAS or Robarts Histologic Index [ Time Frame: Week 52 ]
15. Time to relapse and exclusion of other causes of an increase in disease activity unrelated tounderlying CD (eg, infections, change in medication) [ Time Frame: Week 52 ]
16. Proportion of participants with a Crohn's Disease Endoscopic Index of Severity (CDEIS) decrease from baseline of ≥ 50% [ Time Frame: Week 52 ]

Eligibility Criteria
Ages Eligible for Study: 18 to 75 Years (Adult, Older Adult)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Criteria

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please visit: www.BMSStudyConnect.com

Inclusion Criteria:

Fulfilled the inclusion criteria at time of entry into the induction study and completed the week 12 efficacy assessments of the induction study In clinical response and/or clinical remission and/or an average daily stool frequency score ≤ 3 and an average abdominal pain score ≤ 1 with abdominal pain and stool frequency no worse than baseline at Week 12 of the Induction Study

Exclusion Criteria:

Partial or total colectomy, small bowel resection, or an ostomy since day 1 of the induction studies or has developed a symptomatic fistula Had a rectal steroid therapy, rectal 5-aminosalicylates, parenteral corticosteroids, immunomodulatory agents, investigational agents or apheresis

Other protocol-defined inclusion/exclusion criteria apply


Contacts and Locations
Contacts

Contact: Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, please email: Clinical.Trials@bms.com

Contact: First line of the email MUST contain the NCT# and Site #.

Locations
United States, Arizona Holland Center for Family Health Peoria
United States, Arizona Elite Clinical Studies, LLC Phoenix
United States, Arizona HonorHealth Research Institute Scottsdale
United States, Arkansas Arkansas Gastroenterology, P.A. North Little Rock
United States, California Sharp Chula Vista Medical Center Chula Vista
United States, California Kindred Medical Institute for Clinical Trials, LLC Corona
United States, California Valley View Internal Medicine Garden Grove
United States, California Valley View Internal Medicine Garden Grove
United States, California UCSD Medical Center La Jolla
United States, California San Diego Clinical Trials La Mesa
United States, California OM Research Lancaster
United States, California Children's Hospital of Los Angeles Los Angeles
United States, California Southern California Research Institute Medical Group, Inc. Los Angeles
United States, California Matrix Clinical Research Inc Los Angeles
United States, California Gastrointestinal Biosciences Los Angeles
United States, California VA Northern California Health Care System Mather
United States, California Facey Medical Foundation (Parent) Mission Hills
United States, California ABS Health, LLC Mission Viejo
United States, California Alliance Clinical Research Oceanside
United States, California Palo Alto Center-Palo Alto Medical Foundation Research Institute Palo Alto
United States, California Havana Research Institute LLC Pasadena
United States, California Inland Empire Liver Foundation Rialto
United States, California Sutter Medical Group Roseville
United States, California UC Davis Health - Gastroenterology and Hepatology Clinical Trials Unit Sacramento
United States, California Medical Associates Research Group San Diego
United States, California University of California at San Francisco San Francisco
United States, California New Hope Research Development West Covina
United States, Colorado Peak Gastroenterology Associates Colorado Springs
United States, Connecticut Connecticut Clinical Research Foundation Bristol
United States, Connecticut Yale University New Haven
United States, Florida Gastro Florida Clearwater
United States, Florida Clinical Research of West Florida Clearwater
United States, Florida South Lake Pain Institute Clermont
United States, Florida American Research Institute Inc Cutler Bay
United States, Florida Universal Axon Clinical Research Doral
United States, Florida Riverside Clinical Research Edgewater
United States, Florida University of Florida Health Endocrinology - Medical Specialties - Medical Plaza Gainesville
United States, Florida Qway Research LLC Hialeah
United States, Florida Floridian Clinical Research LLC Hialeah
United States, Florida Harmony Medical Research Institute Hialeah
United States, Florida The Center for Gastrointestinal Disorders Hollywood
United States, Florida Vista Health Research Homestead
United States, Florida SIH Research Kissimmee
United States, Florida Florida Center for Gastroenterology Largo
United States, Florida Pioneer Clinical Research Lighthouse Point
United States, Florida Center For Advanced Gastroenterology Maitland
United States, Florida Galiz Research LLC Miami Springs
United States, Florida LMG Research Miami
United States, Florida Nova Clinical Research Center LLC Miami
United States, Florida LCC Medical Research Institute, LLC Miami
United States, Florida Research Associates of South Florida LLC Miami
United States, Florida Life Medical Center & Research, Inc. Miami
United States, Florida Vista Health Research Miami
United States, Florida Advanced Research for Health Improvement Naples
United States, Florida Bayside Clinical Research New Port Richey
United States, Florida NSB Research New Smyrna Beach
United States, Florida NSB Research New Smyrna Beach
United States, Florida Omega Research Maitland, LLC Orlando
United States, Florida HMD Research LLC Orlando
United States, Florida IMIC, Inc. Palmetto Bay
United States, Florida Theia Clinical Research, LLC Pinellas Park
United States, Florida Advanced Medical Research Center Port Orange
United States, Florida Precision Clinical Research, LLC. Sunrise
United States, Florida University of South Florida Tampa
United States, Florida Apex Clinical Research Tampa
United States, Florida Guardian Angel Health Svcs Inc Tampa
United States, Florida Asclepes Research Centers Weeki Wachee
United States, Georgia Consultative Gastroenterology Atlanta
United States, Georgia Children's Healthcare of Atlanta Atlanta
United States, Georgia Emory Clinic Atlanta
United States, Georgia Atlanta Gastroenterology Associates, LLC Atlanta
United States, Georgia Children's Center for Digestive Healthcare Atlanta
United States, Georgia Gastrointestinal Disease Research Columbus
United States, Georgia Atlanta Center For Gastroenterology, P.C. Decatur
United States, Georgia Gastroenterology Associates Of Central Georgia LLC Macon
United States, Idaho Grand Teton Research Group, PLLC Idaho Falls
United States, Illinois Rush University Medical Center - University Cardiovascular Surgeons Chicago
United States, Illinois Northwestern University Chicago
United States, Illinois University of Chicago Chicago
United States, Illinois DM Clinical Research Oak Lawn
United States, Illinois Carle Foundation Hospital Urbana
United States, Indiana MediSphere Medical Research Center, LLC Evansville
United States, Indiana Indiana University Indianapolis
United States, Iowa Iowa Digestive Disease Center Clive
United States, Kansas Cotton ONeil Clinical Research Center Digestive Health Topeka
United States, Kentucky University of Kentucky Health Care Lexington
United States, Louisiana Gastroenterology Associates, LLC Baton Rouge
United States, Louisiana CroNOLA LLC Houma
United States, Louisiana Centex Studies, Inc. Lake Charles
United States, Louisiana Clinical Trials of SW Louisiana LLC Lake Charles
United States, Louisiana Tandem Clinical Research, LLC Marrero
United States, Louisiana Nola Research Works New Orleans
United States, Louisiana LSU Health Sciences Center Shreveport Shreveport
United States, Maryland Johns Hopkins Bayview Medical Center Baltimore
United States, Maryland Digestive Disease Associates, PA Catonsville
United States, Maryland Woodholme Gastroenterology Associates Glen Burnie
United States, Massachusetts Harvard Medical School - Boston Children's Hospital Boston
United States, Massachusetts Brigham and Women's Hospital - Crohn's and Colitis Center Chestnut Hill
United States, Massachusetts Baystate Medical Center Springfield
United States, Massachusetts Local Institution - 286 Springfield
United States, Massachusetts University of Massachusetts Memorial Medical Center Worcester
United States, Michigan Medex Research Institute Caro
United States, Michigan Western Michigan University Homer Stryker M.D. School of Medicine Kalamazoo
United States, Michigan Henry Ford Medical Center - New Center One Novi
United States, Michigan Revive Research Institute Southfield
United States, Minnesota University of Minnesota Medical Center Minneapolis
United States, Minnesota Mayo Clinic Rochester
United States, Mississippi Southern Therapy and Advanced Research Jackson
United States, Missouri Mid America Gastrointestinal Consultants Kansas City
United States, Missouri Washington University School of Medicine Saint Louis
United States, Nevada Internal Medicine Specialists Las Vegas
United States, New Hampshire Dartmouth-Hitchcock Medical Center Lebanon
United States, New Jersey Englewood Hospital and Medical Center Englewood
United States, New Mexico University of New Mexico Hospital Albuquerque
United States, New York Advantage Clinical Trials Bronx
United States, New York NY Scientific Brooklyn
United States, New York Adirondack Medical Research Center Glens Falls
United States, New York Northwell Health Great Neck
United States, New York Drug Trials America Hartsdale
United States, New York Weill Cornell Medical College New York
United States, New York Concorde Medical Group New York
United States, New York Cornell University New York
United States, New York TrialSpark New York
United States, New York Lenox Hill Hospital New York
United States, New York DiGiovanna Institute for Medical Education And Research North Massapequa
United States, New York Circuit Clinical Orchard Park
United States, North Carolina Asheville Gastroenterology Associates, P.A. Asheville
United States, North Carolina Carolinas HealthCare System Digestive Health Charlotte
United States, North Carolina Internal Medicine Research Charlotte
United States, North Carolina PMG Research of Charlotte LLC Charlotte
United States, North Carolina Carolina Research Center Greenville
United States, North Carolina PMG Research of Winston-Salem LLC Winston-Salem
United States, Ohio Great Lakes Medical Research, LLC Beachwood
United States, Ohio University Hospitals of Cleveland Cleveland
United States, Ohio Cleveland Clinic - Taussig Cancer Institute Cleveland
United States, Ohio Local Institution - 018 Cleveland
United States, Ohio Advance Clinical Research - Dayton Internal Medicine Dayton
United States, Ohio Ohio State University Wexner Medical Center Hilliard
United States, Ohio Great Lakes Gastroenterology Mentor
United States, Ohio Paramount Medical Research & Consulting, LLC Middleburg Heights
United States, Ohio Great Lakes Medical Research, LLC Warren
United States, Oklahoma Cancer Care Associates of OK-N PorterAvenue Norman
United States, Oklahoma Hightower Clinical Oklahoma City
United States, Oklahoma University of Oklahoma Health Sciences Center Oklahoma City
United States, Oklahoma Digestive Disease Specialists Oklahoma City
United States, Oklahoma Allergy, Asthma and Immunology Center, PC Tulsa
United States, Oklahoma Central States Research, LLC Tulsa
United States, Oregon Oregon Health & Science University Portland
United States, Pennsylvania Penn State Milton S Hershey Medical Center Hershey
United States, Pennsylvania University of Pennsylvania Cancer Center Philadelphia
United States, Pennsylvania Penn State University Milton S Hershey Medical Center State College
United States, Tennessee Local Institution - 121 Nashville
United States, Tennessee Quality Medical Research Nashville
United States, Tennessee Vanderbilt University Medical Center Nashville
United States, Tennessee Advanced Gastroenterology Union City
United States, Texas Avant Research Associates, LLC - Austin Austin
United States, Texas San Antonio Military Medical Center Fort Sam Houston
United States, Texas Baylor College of Medicine Houston
United States, Texas Houston Methodist Hospital Houston
United States, Texas Biopharma Informatic Inc. Research Center Houston
United States, Texas Centex Studies, Inc. Houston
United States, Texas GI Specialists of Houston Houston
United States, Texas Local Institution - 088 Houston
United States, Texas Premier Vein and Vascular Center Houston
United States, Texas The Coastal Medical Group Houston
United States, Texas Gulf Coast Research Group LLC Houston
United States, Texas Accurate Clinical Research Inc Pasadena
United States, Texas DHAT Research Institute Richardson
United States, Texas Sun Research Institute San Antonio
United States, Texas Sun Research Institute San Antonio
United States, Texas San Antonio Gastroenterology San Antonio
United States, Texas Texas Digestive Disease Consultants - Southlake Southlake
United States, Texas Baylor Scott and White Health Temple
United States, Texas Digestive Health Specialists of Tyler Tyler
United States, Utah University of Utah School of Medicine Salt Lake City
United States, Virginia Gastroenterology Associates, PC Gainesville
United States, Virginia Local Institution - 189 Gainesville
United States, Virginia Blue Ridge Medical Research Lynchburg
United States, Virginia Summit Clinical Research, LLC Petersburg
United States, Virginia The Gastroenterology Group Reston
United States, Virginia McGuire Veterans Affairs Medical Center Richmond
United States, Virginia Carilion Clinic Roanoke
United States, Virginia Virginia Gastroenterology Institute PC Suffolk
United States, Washington University of Washington Medical Center Seattle
United States, Washington Dermatologist Specialists of Spokane Spokane
United States, Wisconsin Aurora Health Care Aurora Research Grafton
United States, Wisconsin Franciscan Skemp Healthcare La Crosse
Argentina Sanatorio Guemes Ciudad Autonoma de Buenos Aires
Argentina Hospital Privado Centro Medico de Cordoba Cordoba
Argentina Instituto Medico de la Fundacion Estudios Clinicos Rosario
Argentina Universidad Nacional De Rosario - Hospital Provincial Del Centenario Rosario
Argentina Sanatorio 9 de Julio - CICE 9 de Julio San Miguel de Tucuman
Australia, New South Wales Concord Repatriation General Hospital Concord
Australia, New South Wales Nepean Hospital Kingswood
Australia, New South Wales Liverpool Hospital Liverpool
Australia, New South Wales John Hunter Hospital and Hunter Medical Research Institute New Lambton Heights
Australia, New South Wales Wollongong Hospital Wollongong
Australia, Queensland Coastal Digestive Health Maroorchydore
Australia, Queensland Local Institution - 313 Maroorchydore
Australia, Queensland University of the Sunshine Coast North Mackay
Australia, Queensland Mater Hospital Brisbane South Brisbane
Australia, Queensland Princess Alexandra Hospital Woolloongabba
Australia, South Australia Local Institution - 308 Adelaide
Australia, South Australia Royal Adelaide Hospital Adelaide
Australia, South Australia Flinders Medical Centre Bedford Park
Australia, South Australia The Queen Elizabeth Hospital Woodville South
Australia, Victoria Monash Medical Centre Clayton
Australia, Victoria St Vincent's Hospital Melbourne Fitzroy
Australia, Western Australia Harry Perkins Medical Research Institute, Fiona Stanley Hospital Murdoch
Australia, Western Australia St John of God Subiaco Hospital Subiaco
Australia Ballarat Base Hospital Ballarat
Austria Medical University Innsbruck Innsbruck
Austria Local Institution - 727 St Polten
Austria University Hospital St. Poelten St Polten
Austria Medical University Vienna Vienna
Belarus Grodno City Clinical Hospital #4 Grodno
Belarus Vitebsk Regional Clinical Specialized Center Vitebsk
Belgium Algemeen Ziekenhuis Klina Brasschaat
Belgium Universitair Ziekenhuis Brussel Brussels
Belgium University Hospital Brussels Brussels
Belgium CHU Saint-Luc Brussels
Belgium Queen Fabiola Children's University Hospital Brussels
Belgium Universitair Ziehenhuis Antwerpen Edegem
Belgium Universitair Ziekenhuis Gent Ghent
Belgium Universitair Ziekenhuis Leuven, Campus Gasthuisberg Leuven
Belgium Clinique du Montlegia Liege
Belgium Sart Tilman Hospital Department of Gastroenterology and Hepatology Seraing
Belgium Hospital Centre of Walloon Picarde Tournai
Bosnia and Herzegovina University Clinical Centre of the Republic of Srpska Banja Luka
Bosnia and Herzegovina University Clinical Hospital Mostar Mostar
Bosnia and Herzegovina Clinical Center University of Sarajevo Sarajevo
Bosnia and Herzegovina General Hospital "Prim.dr. Abdulah Nakas" Sarajevo
Bulgaria Multiprofile Hospital for Active Treatment Medline Plovdiv
Bulgaria MHAT Ruse AD Ruse
Bulgaria Second MHAT Sofia AD Sofia
Bulgaria Excelsior Medical Center Sofia
Bulgaria Local Institution - 750 Sofia
Bulgaria Multiprofile Hospital for Active Treatment Tokuda Hospital Sofia Sofia
Bulgaria Diagnostic and Consulting Center Alexandrovska Sofia
Bulgaria University Multiprofile Hospital for Active Treatment Tsaritsa Yoanna ISUL EAD Sofia
Bulgaria University Multiprofile Hospital for Active Treatment Sveti Ivan Rilski EAD Sofia
Bulgaria Diagnostic-Consultative Center Sveta Anna Sofia
Bulgaria University Multiprofile Hospital for Active Treatment ACIBADEM City Clinic Sofia Sofia
Bulgaria ACIBADEM City Clinic Medical Center Bregalnitsa Varna
Canada, Alberta University of Calgary Health - The Gastrointestinal Research Group (GIRG) Calgary
Canada, Alberta West Edmonton Gastroenterology Consultants Edmonton
Canada, British Columbia Okanagan Clinical Trials Ltd Kelowna
Canada, British Columbia Fraser Clinical Trials Inc. New Westminister
Canada, British Columbia Vancouver Hospital Gastrointestinal Research Unit The Gordon and Leslie Diamond Centre Vancouver
Canada, British Columbia GI Research Institute Vancouver
Canada, British Columbia Local Institution - 267 Vancouver
Canada, Manitoba Brandon Medical Arts Clinic Brandon
Canada, Manitoba Local Institution - 256 Brandon
Canada, Manitoba Winnipeg Clinic Dermatology Research Winnipeg
Canada, Nova Scotia Viable Clinical Research Bridgewater
Canada, Nova Scotia IWK Health Center Halifax
Canada, Ontario Local Institution - 252 London
Canada, Ontario London Health Sciences Centre, University Hospital London
Canada, Ontario LHSC Victoria Hospital London
Canada, Ontario Dr.Garisa Jagan Mohan Reddy MD Sudbury
Canada, Ontario Mount Sinai Hospital Toronto
Canada, Ontario Kensington Screening Clinic Toronto
Canada, Ontario Toronto Digestive Disease Associates Inc Vaughan
Canada, Quebec Hopital Maisonneuve-Rosemont Montreal
Canada, Quebec The Ottawa Hospital - General Campus Ottawa
China Peking University First Hospital Beijing
China Peking University People's Hospital Beijing
China Beijing YouYi Hospital-Beijing Friendship Hospital Capital Medical University Beijing
China The Seventh Medical Center of PLA General Hospital Beijing
China First Hospital of Jilin University Changchun
China Guangzhou First People's Hospital Guangzhou Shi
China Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University Hangzhou, Zhejiang
China Anhui Provincial Hospital Hefei
China The First Affiliated Hospital of Nanchang University Nanchang
China Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University Nanjing
China Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai
China China Medical University Hospital Taichung City
China Wuhan Union Hospital Wuhan
China Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology Wuhan
China Zhangzhou Municipal Hospital of Fujian Province Zhangzhou
China The Second Affiliated Hospital Of Zhengzhou University Zhengzhou
Croatia Clinical Hospital Center Osijek Osijek
Croatia Clinical Hospital Centre Rijeka Rijeka
Croatia Clinical Hospital Center Split Split
Croatia Clinical Hospital Center Sestre milosrdnice Clinic of Internal Diseases Zagreb
Croatia Clinical Hospital Dubrava Zagreb
Croatia University Hospital Centre Zagreb, Clinic of Internal Diseases Zagreb
Czechia Local Institution - 767 Brno
Czechia Military Hospital Brno Brno
Czechia Local Institution - 772 Brno
Czechia St. Anne's University Hospital Brno Brno
Czechia Hepato-Gastroenterologie HK, s. r. o. Hradec Králové
Czechia Soukroma Gastroenterologicka ambulance a endoskopie Most
Czechia PreventaMed Olomouc
Czechia Krajská nemocnice Pardubice, Kožní oddelení Pardubice
Czechia University Hospital Pilsen Plzen
Czechia University Hospital Motol Prague 5
Czechia ISCARE, a.s. Prague 9
Czechia Institut klinicke a experimentalni mediciny Praha 4
Czechia Local Institution - 776 Praha 4
Denmark Bispebjerg Hospital Copenhagen
Denmark Holbaek Hospital Holbaek
Denmark Nykobing F Hospital Nykobing F
Finland Helsinki University Central Hospital (HUCH) Helsinki
Finland Turku University Hospital Turku
France CHU Amiens Picardie - Site Sud Amiens cedex 1
France Centre Hospitalier de Blois Blois Cedex
France Beziers Hospital Béziers
France University Hospital Center Caen Caen
France Assistance Publique - Hopitaux de Paris - Hopital Beaujon Clichy
France Louis Mourier Hospital Colombes
France Centre Hospitalier Intercommunal de Creteil Creteil Cedex
France CHU de Dijon Bourgogne - Hopital Francois Mitterand Dijon Cedex
France CHU de Grenoble Alpes Grenoble Cedex 9
France Local Institution - 615 Grenoble Cedex 9
France CHRU de Lille - Hopital Claude Huriez Lillie Cedex
France Hopital Nord Marseille cedex 20
France CHU Nantes University Hospital - Hotel Dieu Hospital Nantes
France South Lyon Hospital Center Pierre-Benite
France Hospital Pontchaillou Rennes
France CHU de Rouen Hopital Charles Nicolle Rouen Cedex
France Saint-Etienne University Hospital Center Saint Priest en Jarez
France CHU de Toulouse Hopital Rangueil Toulouse Cedex 09
Georgia JSC Evex Medical Corporation - Batumi Referral Hospital Batumi
Georgia JSC Evex Medical Corporation - Oncology Center Kutaisi
Georgia Helsicore - Israeli Georgian Medical Research Clinic Tbilisi
Georgia LLC Vivamedi Tbilisi
Georgia Tbilisi State Medical University Tbilisi
Georgia LTD Institute of Clinical Cardiology Tbilisi
Georgia JSC Infectious Disease, AIDS and Clinical Immunology Research Center Tbilisi
Georgia Local Institution - 783 Tbilisi
Georgia Local Institution - 784 Tbilisi
Georgia Local Institution - 785 Tbilisi
Georgia LTD Academician N.Kipshidze Central University Clinic Tbilisi
Georgia LTD Aversi Clinic Tbilisi
Georgia LTD MediClub Georgia Tbilisi
Georgia David Tatishvili Medical Center Tbilisi
Georgia JSC Evex Medical Corporation - Telavi Referral Hospital Telavi
Germany Charite - Universitaetsmedizin Berlin Berlin
Germany Gastroenterological Special Practice at Wittenbergplatz Berlin
Germany Gastroenterology Am Bayerischen Platz Berlin
Germany Charite Universitaetsmedizin Berlin - Campus Benjamin Franklin Berlin
Germany Charite - Universitätsmedizin Berlin Berlin
Germany DRK Clinics Berlin Berlin
Germany Hospital Waldfriede e.V. Berlin
Germany Brandenburg City Hospital Brandenburg an der Havel
Germany Medical Care Unit Dachau Dachau
Germany Klinikum Darmstadt Darmstadt
Germany Kliniken Essen-Mitte Essen
Germany Johann Wolfgang Goethe University Hospital Frankfurt am Main
Germany Agaplesion Markus Krankenhaus Frankfurt
Germany Interdisciplinary Crohn Colitis Center Rhein Main Frankfurt
Germany Studiengesellschaft BSF Halle
Germany University Hospital Halle (Saale) Halle
Germany University Hospital Hamburg-Eppendorf Hamburg
Germany Asklepios Klinik Hamburg Hamburg
Germany Universitatsklinikum Schleswig-Holstein Keil
Germany Universitaetsklinikum Leipzig AoeR Leipzig
Germany Practice for Gastroenterology and Internal Medicine Ludwigshafen am Rhein
Germany St Marien und St Annastiftskrankenhaus Ludwigshafen am Rhein
Germany Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz Mainz
Germany University Hospital Muenster Muenster
Germany Synesis Research Center Munich
Germany Universitaetsklinikum Charite - Ruppiner Kliniken GmbH Neuruppin
Germany Robert-Bosch-Hospital Stuttgart
Germany Universitaetsklinikum Tuebingen Tuebingen
Germany Universitaetsklinikum Ulm Ulm
Greece Laiko General Hospital of Athens Athens
Greece Sotiria Chest Diseases Hospital of Athens Athens
Greece Tzanio General Hospital of Piraeus Athens
Greece PAGNI University Hospital Heraklion
Greece General Hospital of Thessaloniki Hippokration Thessaloniki
Greece 424th Army General Hospital Thessaloniki
Hungary Bekes Megyei Kozponti Korhaz Dr. Rethy Pal Tagkorhaz Bekescsaba
Hungary Local Institution - 798 Bekescsaba
Hungary Magyar Honvedseg Egeszsegugyi Kozpont Budapest
Hungary Semmelweis Egyetem - Altalanos Orvostudomanyi Kar Budapest
Hungary Petz Aladar Megyei Oktato Korhaz,II. Belgyogyaszat Gyor
Hungary CRU Hungary Kft Miskolc
Hungary Kanizsai Dorottya Hospital Nagykanizsa
Hungary Local Institution - 800 Nagykanizsa
Hungary Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz Szekesfehervar
Hungary Clinfan Ltd Szekszárd
Hungary Csongrad County Dr. Bugyi Istvan Hospital Szentes
Hungary Zala Megyei KorhazHaematologia Zalaegerszeg
Ireland, Dublin St Vincent's University Hospital Dublin 4
Ireland Beaumont Hospital Dublin 9
Israel Institute of Gastroenterology and Hepatology at Ha'Emek Medical Center Afula
Israel Bat Yamon Medical Center, Clalit Medical Services Bat Yam
Israel Asaf Harofeh Medical Center Beer Jacob
Israel Rambam Health Care Campus Haifa
Israel Shaare Zedek Medical Center Jerusalem
Israel Clalit Health Services Jerusalem
Israel Meir Medical Center Kfar-Saba
Israel Galilee Medical Center Nahariya
Israel Local Institution - 344 Nahariya
Israel Rabin Medical Center Petah Tikva
Israel Chaim Sheba Medical Center Ramat Gan
Israel Kaplan Medical Center Rechovot
Israel Tel-Aviv Sourasky Medical Center Tel-Aviv
Italy University Polyclinic Hospital of Bari Bari
Italy Local Institution - 677 Bologna
Italy Polyclinic S. Orsola-Malpighi Bologna
Italy Civil Hospital of Brescia Brescia
Italy Poliambulanza Hospital Brescia
Italy IRCCS "Savario De Bellis" Castellana Grotte
Italy University Hospital Mater Domini Catanzaro
Italy "Ss. Annunziata" Policlinic of Chieti Chieti
Italy University Polyclinic Hospital G. Martino Messina
Italy Maggiore Polyclinic Hospital, IRCCS Ca' Granda Milano
Italy Humanitas Research Hospital - Humanitas Mirasole S.p.A Milan
Italy Azienda Socio Sanitaria Territoriale (ASST) di Monza Monza
Italy Hospital of Di Padova Padova
Italy United Hospitals Villa Sofia Cervello Palermo
Italy Polyclinic San Matteo IRCCS Pavia
Italy Polyclinic Tor Vergata Roma
Italy Univerisity Polyclinic Foundation Agostino Gemelli Roma
Italy Azienda Ospedaliera San Camillo Forlanini Rome
Italy Integrated University Hospital Santa Maria della Misericordia of Udine Udine
Italy A.O. Universitaria Fondazione Macchi Varese
Italy Sacred Heart Don Calabria Verona
Korea, Republic of Korea University Medical Center - Korea University Ansan Hospital Ansan
Korea, Republic of Pusan National University Hospital Busan
Korea, Republic of Inje University Haeundae Paik Hospital Busan
Korea, Republic of Yeungnam University Medical Center Daegu
Korea, Republic of Hanyang University Guri Hospital Guri-si
Korea, Republic of Seoul National University Bundang Hospital Seongnam-si
Korea, Republic of Severance Hospital Seoul
Korea, Republic of Samsung Medical Center Seoul
Korea, Republic of Seoul National University Hospital Seoul
Korea, Republic of Kangbuk Samsung Hospital Seoul
Korea, Republic of Ewha Womans University Mokdong Hospital Seoul
Korea, Republic of St. Vincent's Hospital Suwon
Latvia P. Stradins Clinical University Hospital Riga
Latvia Digestive Diseases Center Gastro Riga
Latvia Riga East Clinical University Hospital clinic Gailezers Riga
Lithuania Hospital of Lithuanian University of Health Sciences Kaunas Clinics Kaunas
Lithuania Klaipeda University Hospital Klaipeda
Lithuania Vilnius University Hospital Santariskes Clinics Vilnius
Lithuania Vilnius University Hospital Santariskiu Klinikos Vilnius
Lithuania Vilnius City Clinical Hospital Vilnius
Mexico, Jalisco Investigacion Biomedica para el desarrollo de Farmacos, S.A. de C.V. Zapapan
Mexico, Nuevo León Centro Regiomontano de Estudios Clinicos Roma SC. Monterrey
Mexico, Nuevo León Instituto Tecnológico y de Estudios Superiores de Monterrey Monterrey
Mexico, Querétaro SMIQ Santiago de Queretaro
Mexico Hospital Christus Muquerza del Parque S.A. de C.V. Chihuahua
Mexico Centro de Investigacion Clinica Acelerada (CICA) S.C. Mexico
Mexico Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran Tlalpan
Moldova, Republic of "Sfanta Treime" Clinical Municipal Hospital Chisinau
Moldova, Republic of Clinical Hospital of the Ministry of Health, Department of Endoscopic Surgery Chisinau
Moldova, Republic of "Sf. Arhanghel Mihail" Municipal Clinical Hospital Chisinau
Moldova, Republic of Republican Clinical Hospital, Department of Colorectal Surgery Chisinau
Moldova, Republic of Republican Clinical Hospital Chisinau
Netherlands Vrije Universiteit Medisch Centrum (VUMC) Amsterdam
Netherlands Academisch Medisch Centrum Amsterdam
Netherlands Local Institution - 955 Amsterdam
Netherlands UMC Groningen Groningen
Netherlands Radboud University Medical Center Nijmegen
Netherlands Zuyderland Medisch Centrum Sittard-Geleen
Netherlands St. Elisabeth Ziekenhuis Tilburg
Norway Akershus University Hospital Lørenskog
Norway Lovisenberg Diakonale Sykehus Oslo
Poland SP ZOZ Wojewodzki Szpital Zespolony im. J. Sniadeckiego Bialystok
Poland Medical Services Center MaxMed Bochnia
Poland St. John Paul 2nd Municipal Hospital in Elblag Elblag
Poland Nicolaus Copernicus Hospital Gdansk
Poland Private Medical Practice Miroslaw Fic Jelenia Gora
Poland BioVirtus Medical Centre Jozefow
Poland Nzoz All-Medicus Katowice
Poland Kornel Gibinski Independent Public Central Clinical Hospital in Katowice Katowice
Poland GLOBE Clinical Research Sp. z o.o. LLC Klodzko
Poland PLEJADY Sp. z o.o. (LLC) Medical Centre Krakow
Poland Landa Specialist Doctor's Offices Krakow
Poland Local Institution - 823 Krakow
Poland Krakow Medical Center LLC Krakow
Poland Centrum Opieki Zdrowotnej Orkan Med Ksawerow
Poland Santa Familia Centrum Badan, Profilaktyki i Leczenia Lodz
Poland Salve Limited Liability Company Limited Partnership, Outpatient Clinic Lodz
Poland LUX MED Centrum Medyczne - Lodz Lodz
Poland Polish Mother's Memorial Hospital - Research Institute Lodz
Poland 1 Military Clinical Hospital in Lublin Lublin
Poland Local Institution - 760 Lublin
Poland Local Institution - 976 Nowy Targ
Poland Non-Public Healthcare Facility Allmedica Clinical Trials Nowy Targ
Poland Local Institution - 830 Olsztyn
Poland Provincial Specialist Hospital in Olsztyn Olsztyn
Poland SOLUMED Medical Center Poznan
Poland Office of Bartosz Korczowski, MD Rzeszow
Poland Endoskopia Sp. z o.o. Sopot
Poland Local Institution - 979 Sopot
Poland TWOJA PRZYCHODNIA Medical Centre of Szczecin LLC Szczecin
Poland GASTROMED Kopon, Zmudzinski and Partners Specialist Centre for Gastroenterology and Endoscopy, Spe Torun
Poland H-T. Medical Center Sp. z o.o. LLC Limited Partnership Tychy
Poland Polimedica Ul. Piotrkowska 177
Poland Maternal Pediatric and Adolescent Healthcare Centre Warsaw
Poland WIP Warsaw IBD Point Warsaw
Poland PRIMA LCC Specialist Clinics Warsaw
Poland Children's Memorial Health Institute Warsaw
Poland Endoterapia PFG LLC, Endotherapy PFG Outpatient Clinic Branch No 1 Warszawa
Poland Niepubliczny Zaklad Opieki Zdrowotnej VIVAMED Warszawa
Poland Health Centre Metabolic Diseases Outpatient Clinic in Wierzchoslawice Wierzchoslawice
Poland Local Institution - 983 Wroclaw
Poland LUX MED Centrum Medyczne - Wroclaw Wroclaw
Poland Wroclaw Medical University Wroclaw
Poland Jan Mikulicz Radecki University Hospital Wroclaw
Poland Clinical Research Center Early-Phase Research Facility Wroclaw
Poland LexMedica Wroclaw
Poland Ars Medica Wroclaw
Poland EMC Medical Institute S.A Wroclaw
Portugal Hospital Universitario de Coimbra- Hospitais de Universidade de Coimbra Coimbra
Portugal Centro Hospitalar do Alto Ave, Hospital da Senhora da Oliveira Guimaraes Guimaraes
Portugal Hospital Beatriz Angelo Loures
Portugal Centro Hospitalar do Alto Minho - Unidade Local de Saúde do Alto Minho, EPE Viana do Castelo
Romania Hyperclinica MedLife Grivita Bucharest
Romania Center of Diagnosis and Treatment Provita Bucharest
Romania Fundeni Clinical Institute Bucharest
Romania Bucharest University Emergency Hospital, Department of Internal Medicine II Bucharest
Romania Dr. Carol Davila Central Military Emergency Clinical Hospital Bucharest
Romania Craiova County Emergency Clinical Hospital Craiova
Romania Colentina Clinical Hospital Napoca
Romania Local Institution - 840 Targu Mures
Romania Targu Mures County Emergency Clinical Hospital Targu Mures
Russian Federation Joint Venture Company Diagnostic Center, Bioterm Ltd. Barnaul
Russian Federation Local Institution - 966 Barnaul
Russian Federation Territorial Clinical Hospital Barnaul
Russian Federation Regional Clinical Hospital #3 Chelyabinsk
Russian Federation Chelyabinsk Regional Clinical Hospital Chelyabinsk
Russian Federation Local Institution - 991 Chelyabinsk
Russian Federation Chita State Medical Academy Chita
Russian Federation Ural State Medical Academy - Medical Association Novaya Bolnitsa Ekaterinburg
Russian Federation Irkutsk State Medical Academy of Postgraduate Education Irkutsk
Russian Federation Immanuel Kant Baltic Federal University Kaliningrad
Russian Federation Kaluga Regional Hospital Kaluga
Russian Federation City Clinical Hospital No 7 - Kazan Kazan
Russian Federation S.V. Beliaev Kemerovo Regional Clinical Hospital Kemerovo
Russian Federation Regional Clinical Hospital Khanty-mansiysk
Russian Federation Federal Siberian Research and Clinical Center Krasnoyarsk
Russian Federation Local Institution - 927 Krasnoyarsk
Russian Federation Moscow Clinical Scientific and Practical Center Moscow
Russian Federation City Clinical Hospital n.a. V.M. Buyanov Moscow
Russian Federation Local Institution - 995 Moscow
Russian Federation City Clinical Hospital 24 Moscow
Russian Federation CJSC Nasledniki Moscow
Russian Federation A.N. Ryzhikh State Research Center for Coloproctology Moscow
Russian Federation Railway Station Clinical Hospital Nizhny Novgorod
Russian Federation Novosibirskiy Gastrocenter Novosibirsk
Russian Federation Local Institution - 853 Novosibirsk
Russian Federation Medical Center Sibnovomed LLC Novosibirsk
Russian Federation Scientific Research Institute of Physiology and Basic Medicine Novosibirsk
Russian Federation Euromed Multi-Specialty Center for Contemporary Medicine LLC Omsk
Russian Federation Medical Diagnostic Center LLC Orenburg
Russian Federation N.N. Burdenko Penza Regional Clinical Hospital Penza
Russian Federation Republican Hospital na VA Baranov Petrozavodsk
Russian Federation Evromedservis Pushkin
Russian Federation Local Institution - 859 Pushkin
Russian Federation Clinic UZI 4D, LLC Pyatigorsk
Russian Federation Pyatigorsk City Hospital 2 Pyatigorsk
Russian Federation Local Institution - 883 Rostov-on-Don
Russian Federation Rostov State Medical University Rostov-on-Don
Russian Federation Medical Center Reavita Med Spb LLC Saint Petersburg
Russian Federation City Clinical Hospital No 31 - St. Petersburg Saint Petersburg
Russian Federation S.M. Kirov Military Medical Academy Saint-Petersburg
Russian Federation Medical University REAVIZ Samara
Russian Federation Samara Station Railway Clinical Hospital under OAO Russian Railways Samara
Russian Federation Local Institution - 992 Saratov
Russian Federation Regional Clinical Hospital Saratov
Russian Federation Sochi City Hospital No 5 Sochi
Russian Federation S.M. Kirov Military Medical Academy St Petersburg
Russian Federation Oncology Center of Moskovskiy District St Petersburg
Russian Federation City Outpatient Care Unit No 38 St. Petersburg
Russian Federation I.I. Mechnikov North-Western State Medical University St. Petersburg
Russian Federation Local Institution - 993 St. Petersburg
Russian Federation State Unitary Enterprise Passengeravtotrans St. Petersburg
Russian Federation Clinical and Diagnostic Center with an outpatient department under the Presidential Executive Office St. Petersburg
Russian Federation Local Institution - 856 St. Petersburg
Russian Federation SPb SBIH City Hospital of Saint Martyr Elizaveta St. Petersburg
Russian Federation Medical Center Eko-Bezopasnost LLC St. Petersburg
Russian Federation Budget Institution of the Khanty-Mansiysk Autonomous Okrug - Ugra Surgut Regional Clinical Hospital Surgut
Russian Federation Tomsk Regional Clinical Hospital Tomsk
Russian Federation Tula Regional Clinical Hospital Tula
Russian Federation G.G. Kuvatov Republican Clinical Hospital Ufa
Russian Federation City Clinical Hospital #21 Ufa
Russian Federation Ulyanovsk Regional Clinical Hospital Ulyanovsk
Russian Federation Novgorod Regional Clinical Hospital Veliky Novgorod
Russian Federation Regional Clinical Hospital Vladimir
Russian Federation Primorsky Regional Clinical Hospital No.1 Vladivostok
Russian Federation Medical Center of Far-Eastern Federal University Vladivostok
Russian Federation Medical Scientific Manufacturing Association Dvizheniye Clinic Volgograd
Saudi Arabia King Fahad Specialist Hospital Dammam
Saudi Arabia King Abdul Aziz University Hospital Jeddah
Saudi Arabia Local Institution - 537 Jeddah
Saudi Arabia King Saud Medical Complex Riyadh
Saudi Arabia King Fahad National Guard Hospital Riyadh
Serbia Clinical Hospital Center Bezanijska Kosa, Clinic of Internal Medicine Belgrade
Serbia Clinical Hospital Center - Dr. Dragisa Misovic-Dedinje Belgrade
Serbia Clinical Hospital Center Zvezdara Clinic of Internal Diseases Belgrade
Serbia Military Medical Academy, Clinic of Gastroenterology and Hepatology Belgrade
Serbia Clinical Center Kragujevac Kragujevac
Serbia Clinical Center of Vojvodina, Clinic of Gastroenterology and Hepatology Novi Sad
Serbia General Hospital Pancevo Pancevo
Serbia General Hospital Djordje Jovanovic Zrenjanin Zrenjanin
Slovakia Cliniq, s.r.o. Bratislava
Slovakia Univerzitna nemocnica Bratislava, Nemocnica Ruzinov Bratislava
Slovakia Brezno gastroenterology center s.r.o. Brezno
Slovakia KM Management, spol. s r.o. Nitra
Slovakia Gastromedic s.r.o. Nove Zamky
Slovakia GASTRO I., s.r.o. Presov
Slovakia World of the Health Inc. General Hospital Rimavska Sobota Rimavska Sobota
Slovenia General Hospital Celje Celje
South Africa Ahmed Kathrada Private Hospital Gauteng
South Africa Emmed Research Pretoria
Spain General University Hospital of Alicante Alicante
Spain University Hospital Germans Trias i Pujol Badalona
Spain Teknon Medical Center Barcelona
Spain University Hospital Reina Sofia Cordoba
Spain University Hospital of Girona Dr. Josep Trueta Girona
Spain University Hospital of the Canary Islands (HUC) La Laguna La Laguna
Spain Hospital Universitario de Gran Canaria Dr. Negrin Las Palmas de Gran Canaria
Spain University Hospital de La Princesa Madrid
Spain Hospital Clinico San Carlos Madrid
Spain Local Institution - 692 Madrid
Spain University Hospital La Paz Madrid
Spain University Hospital Puerta de Hierro Majadajonda Majadahonda, Madrid
Spain University Hospital Marques de Valdecilla (HUMV) Santander
Spain University Hospital Virgen Macarena Sevilla
Spain University Hospital Virgen del Rocio Sevilla
Spain University Clinical Hospital of Valencia Valencia
Spain Viladecans Hospital Viladecans
Spain University Hospital Miguel Servet Zaragoza
Sweden Saint Goran Hospital Stockholm
Sweden Ersta Hospital Stockholm
Switzerland Lindenhofspital Bern
Switzerland Cantonal Hospital Saint Gallen St.Gallen
Switzerland University Hospital Zurich Zurich
Taiwan Kaohsiung Medical University Hospital Kaohsiung, San Ming Dist.
Taiwan E-DA Hospital Kaohsiung
Taiwan Bulent Ecevit Universitesi Uygulama ve Arastirma Hastanesi Kozlu
Taiwan Chang Gung Medical Foundation, Kaohsiung Memorial Hospital Niao-Sung Hsiang Kaohsiung County
Taiwan National Cheng Kung University Hospital Tainan, Taiana
Taiwan Chang Gung Memorial Hospital- Linkou Taoyuan City
Taiwan Taipei Veterans General Hospital Tapei, Beitou Dist.
Taiwan Local Institution - 465 Tapei
Taiwan National Taiwan University Hospital Tapei
Turkey Hacettepe Universitesi Ankara
Turkey Ankara University Medical Faculty Cebeci Hospital Ankara
Turkey Uludag Universitesi Tip Fakultesi Bursa
Turkey Firat University Medical Faculty Elazig
Turkey Bezmialem Foundation University Medical Faculty Istanbul
Turkey Istanbul University Cerrahpasa Medical Faculty Istanbul
Turkey Sultan Abdulhamid Han Egitim ve Arastirma Hastanesi Istanbul
Turkey Marmara University Istanbul
Turkey Istanbul Medeniyet Uni Goztepe Training&Res Hosp Istanbul
Turkey Goztepe Prof. Dr. Suleyman Yalcin City Hospital Kadiköy/Istanbul
Turkey Karadeniz Teknik Universitesi Tip Fakultesi Farabi Hastanesi Trabzon
Ukraine Chernivtsi Regional Clinical Hospital Chernivtsi
Ukraine Chernivtsi Regional Clinical Hospital Chernivtsi
Ukraine Dnipropetrovsk II Mechnykov Regional Clinical Hospital Surgery Department 2 Dnipropetrovsk
Ukraine Si Institute Of Gastroenterology Of Namsu Dept Of Stomach And Duodenum Diseases Dnipropetrovsk
Ukraine Ivano-Frankivsk Regional Clinical Hospital Ivano-Frankivsk
Ukraine Ivano-Frankivsk Central City Clinical Hospital Ivano-Frankivsk
Ukraine V.T. Zaitsev Institute of General and Emergency Surgery Kharkiv
Ukraine Kharkiv City Clinical Hospital 2 Kharkiv
Ukraine Khmelnytskyi Regional Hospital Khmelnytskyi
Ukraine Medical and Diagnostic Center Acinus Kropyvnytskyi
Ukraine Medical Center Medical Clinic Blagomed LLC Kyiv
Ukraine Kyiv City Clinical Hospital #18 Kyiv
Ukraine Kyiv City Clinical Hospital #18 Kyiv
Ukraine BIK-KYIV Ukrainian German Gastroenterology Center Kyiv
Ukraine Medical Center Consilium Medical Kyiv
Ukraine Local Institution - 911 Kyiv
Ukraine Ok Clinic Medical Center within International Institute of Clinical Trials, LLC Kyiv
Ukraine Kyiv Regional Hospital #2 Kyiv
Ukraine Kyiv Regional Clinical Hospital Kyiv
Ukraine Local Institution - 590 Lutsk
Ukraine Volyn Regional Clinical Hospital Lutsk
Ukraine Lviv Regional Clinical Hospital Lviv
Ukraine Public City Clinical Hospital of Emergency Medical Care Lviv
Ukraine Local Institution - 902 Odesa
Ukraine Odesa Regional Clinical Hospital Regional Gastroenterology Center Surgery Department Odesa
Ukraine Poltava M.V. Sklifosovskyi Regional Clinical Hospital under Poltava Regional Council Poltava
Ukraine Ternopil City Public Emergency Medical Care Hospital Ternopil
Ukraine Local Institution - 909 Vinnytsia
Ukraine Vinnytsia City Clinical Hospital #1 Vinnytsia
Ukraine Vinnytsia M.I. Pyrohov Regional Clinical Hospital Vinnytsia
Ukraine Health Clinic, LLC Vinnytsya
Ukraine Multidisciplinary Clinic of the St. Nicholas, LLC Zaporizhia
Ukraine Zaporizhzhya Regional Zaporizhzhya
Ukraine First Private Clinic Zhytomyr
United Kingdom Bristol Royal Infirmary Bristol
United Kingdom Ulster Hospital Dundonald
United Kingdom Queen Elizabeth University Hospital Glasgow
United Kingdom Victoria Hospital Blackpool Lancashire Blackpool
United Kingdom Royal London Hospital London
United Kingdom University College London Hospitals NHS Foundation Trust - University College Hospital London
United Kingdom Guy's and St Thomas' NHS Foundation Trust - Guy's Hospital London
United Kingdom John Radcliffe Hospital Oxford
United Kingdom Royal Shrewsbury Hospital Shrewsbury
United Kingdom University Hospital Southampton NHS Foundation Trust - Southampton General Hospital Southampton
United Kingdom Torbay Hospital Torquay
Sponsors and Collaborators
Celgene
Investigator
Study Director : Bristol-Myers Squibb Bristol-Myers Squibb
More Information
Responsible Party : Celgene
ClinicalTrials.gov Identifier : NCT03464097     
Other Study ID Numbers : RPC01-3203, U1111-1203-8002, 2017-004294-14
First Posted : March 13, 2018
Last Update Posted : July 4, 2022
Last Verified : July 2022
Studies a U.S. FDA-regulated Drug Product: Yes
Studies a U.S. FDA-regulated Device Product: No
Keywords provided by Celgene: Crohn's Disease
Crohn Disease
Oral
Ozanimod
Moderately active
Severely active
RPC01
RPC01-3203
Additional relevant MeSH terms :
Crohn Disease
Inflammatory Bowel Diseases
Gastroenteritis
Gastrointestinal Diseases
Digestive System Diseases
Intestinal Diseases