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At Bolder Science, we want your clinical trial search experience to be the best it can be. Complete the following prompts to easily find the trials you are interested in and see trials recruiting near you. You can adjust these selections in your dashboard after creating your account.

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Study of TRPH-222 in Patients With Relapsed and/or Refractory B-Cell Lymphoma

  • identifier


  • Recruitment Status


  • First Posted

    September 25, 2018

  • Last update posted

    April 1, 2021

Study Description

Brief summary:

This is a Phase 1, multi-center, open-label study of TRPH-222 monotherapy in subjects with relapsed and/or refractory B-cell NHL. The study will be conducted in two Stages: Dose-Escalation, Dose-Expansion.

  • Condition or Disease:
  • Intervention/Treatment:
  • Phase: Phase 1

Detailed Description


Study Design

  • Study Type: Interventional
  • Estimated Enrollment: 120 participants
  • Allocation: Non-Randomized
  • Intervention Model: Sequential Assignment
  • Masking: None (Open Label) ()
  • Primary Purpose: Treatment
  • Official Title: Phase 1, Multicenter, Open-Label Study of the Antibody-Drug Conjugate TRPH-222 in Subjects With Relapsed and/or Refractory B-Cell Lymphoma
  • Actual Study Start Date: October 2018
  • Estimated Primary Completion Date: January 2022
  • Estimated Study Completion Date: August 2022

Outcome Measures

Eligibility Criteria

  • Ages Eligible for Study:
  • Sexes Eligible for Study:
  • Accepts Healthy Volunteers:


Contacts and Locations



Sponsors and Collaborators

More Information

  • Responsible Party:
  • Identifier: NCT03682796 History of Changes
  • Other Study ID Numbers:
  • First Posted: September 25, 2018 Key Record Dates
  • Last Update Posted: April 1, 2021
  • Last Verified: March 2021
  • Individual Participant
    Data (IPD) Sharing

  • Plan to Share IPD: Undecided
  • Studies a U.S. FDA-regulated Drug Product: Yes
  • Studies a U.S. FDA-regulated Device Product: No