- Solid Tumors
- Pipeline Molecules
- Alliance Partners
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Currently, you can access the following clinical trials being conducted worldwide:
Clinicaltrials.gov identifier NCT03921047
Recruitment Status Recruiting
First Posted April 19, 2019
Last update posted May 14, 2019
This research trial studies characterization of T-cell repertoire through next-generation sequencing in patients with acute myeloid leukemia undergoing stem cell transplant. Characterizing T-cell repertoire may help to understand if immune system plays a significant role in high risk patients with acute myeloid leukemia.
PRIMARY OBJECTIVES: I. Characterize the T cell receptor (TCR) repertoire in acute myeloid leukemia (AML) patients before and after receiving hematologic stem cell transplantation (HSCT). II. Identify molecular changes (germline variants and somatic mutations) that contribute to shaping the TCR repertoire. OUTLINE: Patents undergo collection of blood samples before, on day 100, and 1 year after HSCT. Donors undergo collection of blood at the time of HSCT for ribonucleic acid (RNA)-based next generation sequencing of TCRA and TCRB genes.
|: Ancillary-correlative (next generation sequencing)
Patents undergo collection of blood samples before, on day 100, and 1 year after HSCT. Donors undergo collection of blood at the time of HSCT for RNA-based next generation sequencing of TCRA and TCRB genes.
Procedure: Biospecimen Collection
Undergo collection of blood samples
Other: Laboratory Biomarker Analysis
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, , Learn About Clinical Studies.-->
- Diagnosis of AML scheduled to undergo HSCT at University of Southern California (USC)
- Inability to provide consent because of severe mental disorders
- Donor unwilling to provide consent
Contact: Christine Duran 323-865-0371 Duran_C@med.usc.edu
United States, California
USC / Norris Comprehensive Cancer Center
University of Southern California
National Cancer Institute (NCI)
Principal Investigator: Houda Alachkar, PharmD, PhD University of Southern California