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Diagnostic Values of C-reactive Protein and Procalcitonin in Predicting Bacterial Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease

  • Clinicaltrials.gov identifier

    NCT03923803

  • Recruitment Status

    Not yet recruiting

  • First Posted

    April 23, 2019

  • Last update posted

    April 23, 2019

Study Description

Brief summary:

Chronic obstructive pulmonary disease is a serious disease . Exacerbations of Chronic obstructive pulmonary disease is an acute worsening condition of Chronic obstructive pulmonary disease, which always accompanied by clinical symptoms such as, shortness of breath and increased production of sputum. Respiratory infection (bacteria or viruses or mixed) is thought to be the main cause in most exacerbations.

  • Condition or Disease:Chronic Obstructive Pulmonary Disease
  • Intervention/Treatment: Diagnostic Test: C- reactive protein
    Diagnostic Test: Pro calcitonin
  • Phase: N/A

Detailed Description

N/A

Study Design

  • Study Type: Observational
  • Estimated Enrollment: 90 participants
  • Observational Model: Other
  • Time Perspective: Cross-Sectional
  • Official Title: Diagnostic Values of C-reactive Protein and Procalcitonin in Predicting Bacterial Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease
  • Estimated Study Start Date: July 2019
  • Estimated Primary Completion Date: June 2020
  • Estimated Study Completion Date: October 2020

Groups and Cohorts

Groups/Cohorts Intervention/treatment
: Chronic obstructive pulmonary disease
patients with acutely exacerbated Chronic obstructive pulmonary disease admitted in chest department Assiut university hospital ,30 patients who revealed sputum culture and inflammatory markers suggesting infection exacerbation will be followed up
Diagnostic Test: C- reactive protein
the measurement will be done by chemileumeniscence

Diagnostic Test: Pro calcitonin
the measurement will be done by chemileumeniscence

Outcome Measures

  • Primary Outcome Measures: 1. The level of C-reactive protein between Infection and Non-infectious inflammatory response in acute exacerbations of Chronic obstructive pulmonary disease patients [ Time Frame: 24 hours ]
    Patients will be classified into cases with Infection or non-infectious inflammatory response according to the level of C-reactive protein

Eligibility Criteria

  • Ages Eligible for Study: 18 Years and older (Adult, Older Adult)
  • Sexes Eligible for Study: All
  • Accepts Healthy Volunteers: No
  • Sampling Method: Probability Sample
  • Study Population: patients with acutely exacerbated chronic obstructive pulmonary disease

Criteria

Inclusion Criteria:

- Patients admitted to the hospital

Exclusion Criteria:

- patients with malignancies

- patients with other systemic infection

Contacts and Locations

Contacts

Contact: Hanan Omar, MD 01223971654 hananomar1962@gmail.com

Contact: Zeinab Ahmed, MD 01003233267 zeinabdoctor@yahoo.com

Locations

Sponsors and Collaborators

Assiut University

More Information

  • Responsible Party: Assiut University
  • ClinicalTrials.gov Identifier: NCT03923803 History of Changes
  • Other Study ID Numbers: CRPPC
  • First Posted: April 23, 2019 Key Record Dates
  • Last Update Posted: April 23, 2019
  • Last Verified: April 2019
  • Studies a U.S. FDA-regulated Drug Product: No
  • Studies a U.S. FDA-regulated Device Product: No
  • Additional relevant MeSH terms: Bacterial Infections
    Lung Diseases
    Lung Diseases, Obstructive
    Pulmonary Disease, Chronic Obstructive