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Currently, you can access the following clinical trials being conducted worldwide:
Clinicaltrials.gov identifier NCT03923829
Recruitment Status Not yet recruiting
First Posted April 23, 2019
Last update posted April 23, 2019
To evaluate the effect of systemic administration of zinc on the gingival crevicular fluid level of total oxidant capacity in controlled Type-2 diabetic patients with stage-II and III periodontitis after non-surgical periodontal therapy.
Hypozincaemia and hyperzincuria is known to be present in patients with type-2 diabetes, and Zinc supplementation is known to be helpful in restoring plasma Zinc levels to normal,Zinc's deficiency can lead to an increase in circulating glucose due to beta cells malfunctioning and resistance to insulin, which makes it easier for type 2 diabetes mellitus (DM2) to happen ,Zinc was found to be a structural part of key anti-oxidant enzymes such as superoxide dismutase (SOD), and Zinc deficiency impaired their synthesis, leading to increased oxidative stress
|Experimental: Zinc administration with scaling and root planing
systemic administration of Zinc cap of 50 mg elemental zinc as zinc sulphate, once a day for 12 weeks in addition to scaling and root planing
Drug: Zinc Sulfate
systemic administration of Zinc sulfate with scaling and root planing
|Active Comparator: scaling and root planing
scaling and root planing
Procedure: scaling and root planing
scaling and root planing
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, , Learn About Clinical Studies.-->
- Controlled Type-2 diabetes mellitus
- Stage-II &III periodontitis
- At least 2 sites with clinical attachment loss 3 or 4 mm to ≥5 mm and radiographic
bone loss 15% Extending to mid-third of root and beyond.
- Probing depth from ≤5 mm to ≥6 mm
- Any periodontal or Antibiotic treatment during the last six months.
- Receiving trace element supplements in the previous three months
- Pregnant or lactating females
- Gastric or diuretic treatment
- Acute renal failure
Contact: abdulrahman A Abdulrab +201014624724 email@example.com
Contact: Dr. Enji Ahmed, professor +201018941119 firstname.lastname@example.org
Principal Investigator: Dr. Enji Ahmed, professor faculty of dentistry Cairo university
Study Director: Dr. weam elbattawy, Lecturer faculty of dentistry Cairo university
Study Director: Dr. Ollfat Shaker, professor faculty of dentistry Cairo university
Khan MI, Siddique KU, Ashfaq F, Ali W, Reddy HD, Mishra A. Effect of high-dose zinc supplementation with oral hypoglycemic agents on glycemic control and inflammation in type-2 diabetic nephropathy patients. J Nat Sci Biol Med. 2013 Jul;4(2):336-40. doi: 10.4103/0976-9668.117002.
Thomas B, Prasad RB, Shetty S, Vishakh R. Comparative Evaluation of the Lipid Profile in the Serum of Patients with Type II Diabetes Mellitus and Healthy Individuals with Periodontitis. Contemp Clin Dent. 2017 Jan-Mar;8(1):96-101. doi: 10.4103/ccd.ccd_1160_16.