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Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 06/15/2021.

MSOT Using Cetuximab-800CW for Detection of Cervical Lymph Node Metastases

Clinicaltrials.gov identifier NCT03923881

Recruitment Status Recruiting

First Posted April 23, 2019

Last update posted May 3, 2021

Study Description

Brief summary:

The presence of lymph node metastasis is an important factor in determining the appropriate treatment plan in patients with OSCC. However, detection of lymph node metastases by means of current imaging modalities is limited. 20-30% of patients with a clinically negative neck (cN0) harbour lymph node metastasis that were not detected during clinical diagnostic workup, which are referred to as occult lymph node metastasis. Therefore, patients with a risk of lymph node metastasis higher than 20% undergo a sentinel node procedure (SNP) or elective neck dissection (END), which means that a substantial part of patients is overtreated. There is need for an additional non-invasive diagnostic tool that can identify lymph node metastasis and thereby support the decision making for treatment of the neck. The main objective of this study is to evaluate if EGFR-positive cervical lymph node metastasis can be detected non-invasively with multispectral optoacoustic imaging using cetuximab-800CW as contrast agent in patients with oral squamous cell carcinoma.

  • Condition or Disease:Oral Cancer
    Lymph Node Metastases
  • Intervention/Treatment: Device: MSOT Acuity Echo
  • Phase: N/A
Detailed Description

Background: The presence of lymph node metastasis is an important factor in determining the appropriate treatment plan in patients with OSCC. However, detection of lymph node metastases by means of current imaging modalities is limited. 20-30% of patients with a clinically negative neck (cN0) harbour lymph node metastasis that were not detected during clinical diagnostic workup, which are referred to as occult lymph node metastasis. Personalized management of the neck would benefit greatly from staging techniques that increase the accuracy of the assessment of nodal disease. In addition, visualizing the pattern of lymphatic spread can possibly lead to more targeted neck dissections and thereby reduce morbidity. Clearly, there is need for additional diagnostic tools in order to identify lymph node metastasis and thereby support the decision making for treatment of the neck. Optoacoustic imaging is a novel imaging method in which an ultrashort laser pulse is used to irradiate biological tissue. Consequently, optoacoustic or photoacoustic waves are generated which can be measured by wideband ultrasonic transducers. Optoacoustic imaging has been shown to address clinically relevant aspects of various cancers by enabling visualization of targeted tumor-specific biomarkers by detecting optoacoustic waves. We hypothesize that accumulation of cetuximab-800CW can be detected in lymph node metastasis, enabling better visualization of regional metastatic disease compared to current imaging modalities. This approach can improve detection of lymph node metastases and thereby supports decision making for treatment of the neck. Objectives: The main objective of this study is to evaluate if EGFR-positive cervical lymph node metastasis can be detected non-invasively using the MSOT Acuity Echo with cetuximab-800CW as contrast agent in patients with oral squamous cell carcinoma. Study design: The current study is a single center, prospective, cross-sectional, proof of concept study. The study will be carried out by the out at the University Medical Center Groningen, Department of Oral and Maxillofacial Surgery and Department of Nuclear Medicine and Molecular Imaging. Further analysis of sections of the lymph node metastasis will be done at the Department of Pathology. Study population: 20 patients with oral squamous cell carcinoma that have been included in the ICON-study (NCT03134846) and are scheduled for treatment of the neck will be included. Patient related study procedures: Prior to tracer administration as part of the ICON study, optoacoustic imaging is performed. Two-four days later, surgical procedure will take place. One day prior to surgery, the patient is admitted to the hospital and optoacoustic imaging is performed with cetuximab-800CW as contrast agent. Main study endpoints: Quantification of the cetuximab-800CW optoacoustic signal and tracer distribution observed by multispectral optoacoustic imaging using the MSOT Acuity Echo in vivo in patients with oral squamous cell carcinoma. Burden, risks and benefit to participation: Time investment: Patients need to visit the UMCG 2-4 days before their planned surgery according to the ICON-study which will take approximately 2 hours. For the first imaging session, the imaging procedure will take 20-30 minutes and therefore the visit is prolonged with 20-30 minutes. Usually patients are admitted one day prior to surgery. Therefore the second imaging on this day will not require extra time investment, although the imaging procedure takes 20-30 minutes Extra procedures: Two imaging procedures, prior to tracer administration and on day of admission. Both imaging procedures will take 20-30 minutes. Several measures described below have been taken to reduce the risk of injuries to an absolute minimum. The residual risk of MSOT is slight, reversible reddening and temperature increase of the skin. Patients will have no direct benefit from this study.

Study Design
  • Study Type: Interventional
  • Estimated Enrollment: 20 participants
  • Intervention Model: Single Group Assignment
  • Intervention Model Description: 20 patients that have been included in the ICON-study (NCT03134846) and therefore will be administered with cetuximab-800CW
  • Masking: None (Open Label) ()
  • Primary Purpose: Diagnostic
  • Official Title: Multispectral Optoacoustic Imaging Using Cetuximab-800CW for Detection of Cervical Lymph Node Metastases: a Single Center Proof of Concept Study
  • Actual Study Start Date: April 2019
  • Estimated Primary Completion Date: July 2021
  • Estimated Study Completion Date: September 2021
Arms and interventions
Arm Intervention/treatment
Experimental: Study group
Patients with oral squamous cell carcinoma that have been included in ICON-study and are scheduled for treatment of neck
Device: MSOT Acuity Echo
Optoacoustic imaging with the MSOT Acuity Echo
Outcome Measures
  • Primary Outcome Measures: 1. Optoacoustic signal [ Time Frame: A week after imaging is performed ]
    The optoacoustic signal intensity in lymph nodes compared to surrounding tissue
Eligibility Criteria
  • Ages Eligible for Study: 18 Years and older (Adult, Older Adult)
  • Sexes Eligible for Study: All
  • Accepts Healthy Volunteers: No
Criteria

Inclusion Criteria: patients must meet inclusion criteria of the ICON study (NCT03134846),
which are as follows:

- Biopsy confirmed diagnosis of primary or recurrent HNSCC and scheduled to undergo
surgical resection as decided by the Multi-Disciplinary Head & Neck Tumor Board of the
UMCG.

- Age ≥ 18 years

- Written informed consent

- Adequate potential for follow up

- Acceptable hematologic status, kidney function, and liver function, as standard
surgery protocol requires.

Exclusion Criteria:patients must meet exclusion criteria of the ICON study (NCT03134846),
which are as follows:

- Medical or psychiatric conditions that compromise the patient's ability to give
informed consent;

- Concurrent uncontrolled medical conditions;

- Received an investigational drug within 30 days prior to the dose of cetuximab-800CW;

- Tumors at sites of which the surgeon would assess that in vivo imaging would not be
feasible;

- Had within 6 months prior to enrollment: myocardial infarction, cerebrovascular
accident, uncontrolled cardiac heart failure, significant liver disease, unstable
angina;

- Inadequately controlled hypertension with or without current antihypertensive
medications;

- History of infusion reactions to cetuximab or other monoclonal antibody therapies

- Pregnant or lactating women. Documentation of a negative pregnancy test must be
available for women of childbearing potential. Woman of childbearing potential are
premenopausal women with intact reproductive organs and women less than two years
after menopause;

- Evidence of QT prolongation on pretreatment ECG (greater than 440 ms in males or
greater than 450 ms in females);

- Lab values that in the opinion of the primary surgeon would prevent surgical
resection;

- Patients receiving Class IA (quinidine, procainamide) or Class III (dofetilide,
amiodarone, sotalol) antiarrhythmic agents;

- Magnesium, potassium and calcium deviations that might lead to cardiac rhythm (grade
II or higher deviations by CTCAE);

- Life expectancy < 12 weeks; - Karnofsky performance status < 70%.

Contacts and Locations
Contacts
Locations

Netherlands
University Medical Center Groningen
Groningen

Sponsors and Collaborators

University Medical Center Groningen

More Information
  • Responsible Party: University Medical Center Groningen
  • ClinicalTrials.gov Identifier: NCT03923881 History of Changes
  • Other Study ID Numbers: NL67343.042.18
  • First Posted: April 23, 2019 Key Record Dates
  • Last Update Posted: May 3, 2021
  • Last Verified: April 2021
  • Individual Participant
    Data (IPD) Sharing
    Statement:
  • Plan to Share IPD: No
  • Studies a U.S. FDA-regulated Drug Product: No
  • Studies a U.S. FDA-regulated Device Product: No
  • Keywords provided by University Medical Center Groningen: Multispectral Optoacoustic Tomography
    Molecular Imaging
    Cetuximab-800CW
  • Additional relevant MeSH terms: Neoplasm Metastasis Mouth Neoplasms