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Currently, you can access the following clinical trials being conducted worldwide:
Clinicaltrials.gov identifier NCT03924336
Recruitment Status Not yet recruiting
First Posted April 23, 2019
Last update posted April 23, 2019
To assess the effectiveness of advanced PRF as compared to open flap debridement in treatment of periodontal intraosseous defects in stage III periodontitis patients.
The application of platelet concentrates characterized by high concentrations of platelets and growth factors have been applied and investigated as possible periodontal regenerative therapy.The application of platelet rich fibrin in management of intraosseous and furcation defects produce more favorable outcome compared to open flap debridement. A-PRF represents the latest generation of platelet concentrates that could provide sustained and increased release of growth factors and could serve as an autologous cost-effective membrane in periodontal tissue regeneration procedures
|Experimental: Advanced- platelets rich fibrin with open flap debridement
Mucoperiosteal flaps will be elevated using an intrasulcular incision buccally and palatally or lingually.Then the defects will be thoroughly debrided using curettes and ultrasonic scalers.The clinical measurements will be then recorded.After debridement and intraoperative recordings, , one PRF of the required size will be filled into the intraosseous defect, and the other will be used to prepare the membrane that will be used to cover the defect as a barrier. The mucoperiosteal flaps will be repositioned and secured in place using 4-0 silk sutures
Procedure: Advanced- platelets rich fibrin (A-PRF) + open flap debridement
Elevation of flap.Thorough debridedment of the defects using curettes and ultrasonic scalers.clinical measurements will be then recorded , one PRF of the required size will be filled into the intraosseous defect, and the other will be used to prepare the membrane that will be used to cover the defect as abarrier. The mucoperiosteal flaps will be repositioned and secured in place using4-0 silk sutures
|Active Comparator: Open flap debridement
Mucoperiosteal flaps will be elevated using an intrasulcular incision buccally and palatally or lingually.Then the defects will be thoroughly debrided using curettes and ultrasonic scalers.The dclinical measurements will be then recorde.After debridement and intraoperative recordings, The interrupted sutures using 4-0 silk sutures will be placed to reposition the flaps.
Procedure: Open flap debridement alone
Elevation of flap.Thorough debridedment of the defects using curettes and ultrasonic scalers.clinical measurements will be then recorded.After debridement and intraoperative recordings, interrupted sutures using 4-0 silk sutures will be placed to reposition the flaps.
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- Stage III periodontitis patient having at least one tooth with 2-wall, 3-wall, or
combined 2- to 3-wall intraosseous defect ≥ 3 mm in depth (assessed by bone sounding,
radiographic examination) with clinical attachment level (CAL) ≥ 5mm and pocket depth
(PD) ≥ 6 mm.
- Defect not extending to a root furcation area
- Vital teeth
- No history of intake of antibiotics or other medications affecting the periodontium in
the previous 6 months.
- No periodontal therapy carried out in the past 6 months.
- Able to sign an informed consent form.
- Patients age between 25 and 50 years old.
- Patients who are cooperative, motivated, and hygiene conscious.
- Systemically free according to Cornell Medical Index (Broadbent, 1951).
- Pregnancy or breast feeding
- The presence of an orthodontic appliance
- Teeth mobility greater than grade I
Contact: Yasser Abdu 00201003884812 email@example.com
Contact: Manal Hosny firstname.lastname@example.org
Study Director: Manal Hosny, Professor faculty of dentistry Cairo university
Kobayashi E, Flückiger L, Fujioka-Kobayashi M, Sawada K, Sculean A, Schaller B, Miron RJ. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 2016 Dec;20(9):2353-2360. doi: 10.1007/s00784-016-1719-1. Epub 2016 Jan 25.