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Currently, you can access the following clinical trials being conducted worldwide:
Clinicaltrials.gov identifier NCT03925142
Recruitment Status Recruiting
First Posted April 24, 2019
Last update posted July 16, 2020
The purpose of this study is to assess the effects of replacing starchy vegetables and refined grains with beef in a vegetarian diet on cardio-metabolic disease risk factors in adults in a cross-over, randomized controlled feeding trial.
The purpose of this study is to assess the effects of replacing starchy vegetables and refined grains with beef in a vegetarian diet on cardio-metabolic disease risk factors in adults in a cross-over, randomized controlled feeding trial. The hypothesis is that isocalorically replacing predominantly starchy vegetables and refined grains with 6 oz. of beef/day will enhance improvements in cardiometabolic disease risk factors, particularly atherosclerotic-promoting lipids and lipoproteins. It is also hypothesized that participant satisfaction and acceptance of a healthy eating pattern with 6 oz. of beef per day will be higher compared to without beef.
|Active Comparator: Controlled healthy vegetarian diet
Subjects will be randomized and assigned to consume the controlled Healthy Vegetarian Eeating Pattern for 5 weeks.
Other: Controlled healthy vegetarian diet
The controlled healthy vegetarian diet will follow the Dietary Guidelines for American's recommendations. All foods and beverages will be provided during intervention to achieve the desired eating pattern.
|Experimental: Controlled beef diet
Subjects will be randomized and assigned to consume the beef diet for 5 weeks, which will substitute predominantly starchy vegetables and refined grains with 6 oz. of lean unprocessed beef/day.
Other: Controlled beef diet
The controlled beef diet will incorporate various cuts of lean unprocessed red meat into the healthy vegetarian eating pattern, as approved by the American Heart Association's Food Certification Program. The beef diet will isocalorically replace starchy vegetables and/or refined grains with 6 oz. of beef/day for five weeks.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, , Learn About Clinical Studies.-->
- Male or female
- 30-69 years old
- BMI 25-37 kg/m2
- Total cholesterol <260 mg/dL - Low-density lipoprotein cholesterol <190 mg/dL - Glucose <110 mg/dL - Systolic/diastolic blood pressure < 140/90 - Body weight stable for 3 months prior (±3 kg) - Stable physical activity regimen 3 months prior - Medication use stable for 6 months prior - Non-smoking - Not drinking more than 2 alcoholic drinks per day - Non-diabetic - Not lactose-intolerant - Not acutely ill - Non-pregnant and not lactating. - Participants must be willing and able to consume the prescribed diets (lacto-ovo vegetarian and omnivorous). Exclusion Criteria: - 69 years old
- BMI 37 kg/m2
- Fasting serum total cholesterol > 260 mg/dL
- Low-density lipoprotein cholesterol >189 mg/dL
- Glucose >110 mg/dL
- Systolic/diastolic blood pressure > 140/90
- Body weight stable for <3 months prior (±3 kg) - Stable physical activity regimen < 3 months prior - Medication use unstable for 6 months prior and using medications - Smoking - Drinking more than 2 alcoholic drinks per day - Diabetic - Have renal failure - Have liver failure - Have cardiovascular events (myocardial infarction or stroke) during the 6 months prior to the study - Pregnant or lactating
Contact: Jan Green 765-496-6342 email@example.com
Contact: Yu Wang, BS 765-494-7922 firstname.lastname@example.org
United States, Indiana
Principal Investigator: Wayne W Campbell, PhD Purdue University