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Currently, you can access the following clinical trials being conducted worldwide:
Clinicaltrials.gov identifier NCT03927326
Recruitment Status Not yet recruiting
First Posted April 25, 2019
Last update posted April 25, 2019
This study evaluates differences in how administering liposomal bupivacaine via two different methods affects postoperative pain control in laparoscopic abdominal surgery patients. Half the participants will receive liposomal bupivacaine via a transverses abdominis plane block while the other half will receive liposomal bupivacaine via local infiltration.
Liposomal bupivacaine is a newer formulation of a local anesthetic that is commonly used for local infiltration, peripheral nerve blocks, and neuraxial anesthesia. This new formulation allows the effects of bupivacaine to last up to 72 hours as it is slowly released from a liposome. It is FDA approved for local infiltration and has recently been approved for interscalene blocks. A transversus abdominis plane block is a fascial plane block that is performed routinely for postoperative pain relief for some abdominal incisions. It is performed by placing local anesthetic between the internal oblique and transverses abdominis muscle planes where it will provide analgesia to several dermatomes of the abdomen in hopes of improving postoperative pain relief and reducing postoperative opioid requirement.
|Experimental: Local infiltration
Liposomal bupivacaine (266mg) will be directly infiltrated by the surgeon into the surgical laparoscopic wound sites.
Drug: Exparel 266 MG Per 20 ML Injection
|Experimental: Transversus abdominis plane block
Liposomal bupivacaine (266mg) will be used in a ultrasound guided transversus abdominis plane block.
Drug: Exparel 266 MG Per 20 ML Injection
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, , Learn About Clinical Studies.-->
- Patients scheduled for elective laparoscopic colorectal surgery at UWMC requiring
- Patients on chronic pain mediations equaling or exceeding > 25 morphine daily
- Patients allergic to bupivacaine
- Patients with ASA status IV, V, or VI
- Patients unable to consent
- Patients that are pregnant
- Patients that are incarcerated
- Patients receiving procedures in addition to laparoscopic colorectal procedure
- Patients on systemic anticoagulation precluding them from regional blocks
Contact: Alan Chang, MD 714-878-0850 email@example.com
University of Washington
Principal Investigator: Vanessa Loland, MD University of Washington
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