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Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 01/15/2021.

Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements

Clinicaltrials.gov identifier NCT03927638

Recruitment Status Enrolling by invitation

First Posted April 25, 2019

Last update posted September 3, 2020

Study Description

Brief summary:

This investigations examined the effect that posture has on metabolic and cardiovascular measurements. Further, it will explore the potential for body weight status or physical activity to influence these relationships. All subjects will complete a seated condition and a standing condition in a counterbalanced manner.

  • Condition or Disease:Overweight and Obesity
  • Intervention/Treatment: Behavioral: sit/stand
  • Phase: N/A
Detailed Description

The purpose of the present study was to evaluate both metabolic and cardiovascular responses to acute bouts of computer work while sitting and standing. Cardiovascular measurements were made using continuous non-invasive blood pressure monitoring and metabolic measurements were made using indirect calorimetry. Subjects will be grouped and analyzed based upon the weight status of the subject. All subjects will complete a seated condition and a standing condition in a counterbalanced manner. Investigators hypothesize that metabolic and cardiovascular responses will be elevated in the standing condition compared to sitting.

Study Design
  • Study Type: Observational
  • Estimated Enrollment: 80 participants
  • Observational Model: Cohort
  • Time Perspective: Cross-Sectional
  • Official Title: Differences in Sitting Versus Standing on Metabolic and Cardiovascular Measurements
  • Actual Study Start Date: November 2018
  • Estimated Primary Completion Date: May 2022
  • Estimated Study Completion Date: May 2022
Groups and Cohorts
Groups/Cohorts Intervention/treatment
: Normal Weight
Group is determined based upon subjects weight status. Subjects will preform computer work in the seated and standing position in a counterbalanced manner while metabolic and cardiovascular measurements are made.
Behavioral: sit/stand
Subjects will be asked to both sit and stand during a single trial.
: Overweight/Obese
Group is determined based upon subjects weight status. Subjects will preform computer work in the seated and standing position in a counterbalanced manner while metabolic and cardiovascular measurements are made.
Behavioral: sit/stand
Subjects will be asked to both sit and stand during a single trial.
Outcome Measures
  • Primary Outcome Measures: 1. Respiratory Exchange Ration (RER) [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    RER will be calculated using oxygen and carbon dioxide value measure from indirect calorimetry.
  • 2. Ventilation [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Ventilation will be measured using indirect calorimetry.
  • 3. Heart Rate [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure heart rate based upon beat-by-beat finger pressure.
  • 4. Systolic Blood Pressure (SBP) [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure SBP based upon beat-by-beat finger pressure.
  • 5. Diastolic Blood Pressure (DBP) [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to measure DBP based upon beat-by-beat finger pressure.
  • 6. Oxygen Consumption [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Oxygen consumption will be measured using indirect calorimetry.
  • 7. Carbon Dioxide Production [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Carbon Dioxide will be measured using indirect calorimetry.
  • Secondary Outcome Measures: 1. Body Mass Index (BMI) [ Time Frame: 1 minute ]
    Height in meters and weight in kilograms will be used to calculate BMI using the formula BMI = kg/m^2.
  • 2. Height [ Time Frame: 1 minute ]
    Standard stadiometer will be used to measure height in meters.
  • 3. Weight [ Time Frame: 1 minute ]
    Standard scale will be used to measure weight in kilograms.
  • 4. Body Composition [ Time Frame: Approximately 15 minutes ]
    Body composition will be measured using air displacement plethysmography.
  • 5. Total Peripheral Resistance (TPR) [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be uses to estimate TPR based upon beat-by-beat finger pressure.
  • 6. Stroke Volume [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate TPR based upon beat-by-beat finger pressure.
  • 7. Cardiac Output (Q) [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Using human non-invasive blood pressure continuous monitoring placed on the middle finger of the non-dominant hand will be used to estimate Q based upon beat-by-beat finger pressure.
  • 8. Muscle Oxygen Saturation [ Time Frame: Approximately 15 minutes in each condition (sitting and standing) ]
    Using Near-inferred spectroscopy muscle oxygen consumption will be monitored.
Eligibility Criteria
  • Ages Eligible for Study: 18 to 50 Years (Adult)
  • Sexes Eligible for Study: All
  • Accepts Healthy Volunteers:
  • Sampling Method: Probability Sample
  • Study Population: Healthy subjects between the ages of 18 and 50 years.
Criteria

Inclusion Criteria:

- healthy adult

Exclusion Criteria:

- Have a history of cancer, cardiac issues, hypertension, pulmonary disease, stroke,
neurological or muscular dystrophy, uncontrolled diabetes, or any life threatening
chronic conditions.

- Are currently being treated for infectious mononucleosis, hepatitis, pneumonia, or
other infectious diseases.

- Are unable or unwilling to stand in one position continuously for 15-20 minutes at a
time.

- Use nicotine products, or non-contraceptive hormonal therapy (birth control is okay).

- Are pregnant or trying to become pregnant.

- Are not between 18 and 50 years of age.

Contacts and Locations
Contacts
Locations

United States, New Jersey
Montclair State University
Montclair

Sponsors and Collaborators

Montclair State University

More Information
  • Responsible Party: Montclair State University
  • ClinicalTrials.gov Identifier: NCT03927638 History of Changes
  • Other Study ID Numbers: 17-18-861
  • First Posted: April 25, 2019 Key Record Dates
  • Last Update Posted: September 3, 2020
  • Last Verified: September 2020
  • Studies a U.S. FDA-regulated Drug Product: No
  • Studies a U.S. FDA-regulated Device Product: No
  • Additional relevant MeSH terms: Overweight