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Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 06/15/2021.
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Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 06/15/2021.

reGional Network for Acute Myocardial Infarction

Clinicaltrials.gov identifier NCT03928119

Recruitment Status Recruiting

First Posted April 25, 2019

Last update posted April 26, 2019

Study Description

Brief summary:

Incidence of ST-segment Elevation Myocardial Infarction(STEMI) is rising and the existing emergency medical aid system for STEMI was not enough for timely perfusion treatment. No existing research with high-quality data focuses on the characteristic of STEMI incidence and regional network construction. Aiming of Guangdong GAMI(reGional network for Acute Myocardial Infarction) project is to establish effective collaborative regional network system for STEMI patients treatment.

  • Condition or Disease:Acute Myocardial Infarction
    STEMI - ST Elevation Myocardial Infarction
    Coronary Heart Disease
  • Intervention/Treatment: Behavioral: public education and network construction
  • Phase: N/A
Detailed Description

The project of Guangdong GAMI(reGional network for Acute Myocardial Infarction) is being conducted during 2015-2019 in four districts with diverse economic development across Guangdong province. All the ST-segment elevation myocardial infarction (STEMI) patients admitted in the hospital within 30 days from the symptom onset were enrolled and the designed sample size was 4000 patients. The key data of the timeline of STEMI onset and treatment were precisely recorded. Other details of STEMI treatment in hospitals such as laboratory data and medication were also collected. During the research period, actions of both optimizing the regional STEMI patients transfer and treatment to shorten the medical delay, as well as educating the public to improve their awareness of early treatment of STEMI were taken meanwhile. Timeline of STEMI patients visit and treatment were compared before and after every half year to elevate the effect of the actions and optimize the following action to better shorten the treatment delay. In addition, laboratory data, medication, and follow-up information were recorded in a database for further analysis regarding the STEMI patient treatment.

Study Design
  • Study Type: Interventional
  • Estimated Enrollment: 4000 participants
  • Intervention Model: Sequential Assignment
  • Masking: None (Open Label) ()
  • Primary Purpose: Health Services Research
  • Official Title: Construction of Modern reGional Network for Acute Myocardial Infarction
  • Actual Study Start Date: June 2015
  • Estimated Primary Completion Date: May 2019
  • Estimated Study Completion Date: May 2019
Arms and interventions
Arm Intervention/treatment
Experimental: public education and network construction
Public education was conducted to evaluate the effectiveness on patients delay of ST-Segment Elevation Myocardial Infarction treatment. Network construction was conducted to evaluate the effectiveness to minimize the medical delay of ST-Segment Elevation Myocardial Infarction treatment.
Behavioral: public education and network construction
Publication education includes multiple methods of acute myocardial infarction knowledge education. Network construction includes regional connection of ST-Segment Elevation Myocardial Infarction patients transfer for percutaneous coronary intervention treatment, as well as physicians skill improvement in primary hospital.
Outcome Measures
  • Primary Outcome Measures: 1. change of annual average reperfusion time of ST-Segment Elevation Myocardial Infarction patients [ Time Frame: 4 years ]
    annual average reperfusion time of ST-Segment Elevation Myocardial Infarction was analyzed, after public education and network construction, decrease of annual average reperfusion time of STEMI patients were analyzed to testified the effectiveness of the intervention.
  • Secondary Outcome Measures: 1. public awareness of Acute Myocardial Infarction [ Time Frame: 4 years ]
    public awareness of Acute Myocardial Infarction was analyzed by sampling questionnaire survey in each year to conclude the change after the public education intervention
  • 2. change of in-hospital mortality of ST-Segment Elevation Myocardial Infarction [ Time Frame: during hospitalization (an average of 2 weeks) ]
    ST-Segment Elevation Myocardial Infarction patients in-hospital mortality were collected in each year to conclude the in-hospital mortality rate change
  • 3. change of 30-days mortality of ST-Segment Elevation Myocardial Infarction [ Time Frame: 30 days ]
    ST-Segment Elevation Myocardial Infarction patients 30-days mortality were followed up in each year to conclude the mortality rate change
  • 4. change of 1-year mortality of ST-Segment Elevation Myocardial Infarction [ Time Frame: 1 year ]
    ST-Segment Elevation Myocardial Infarction patients 1-year mortality were followed up in each year to conclude the mortality rate change
Eligibility Criteria
  • Ages Eligible for Study: (Child, Adult, Older Adult)
  • Sexes Eligible for Study: All
  • Accepts Healthy Volunteers: No
Criteria

Inclusion Criteria:

- ST-Segment Elevation Myocardial Infarction patients within 30 days since symptoms
onset

Exclusion Criteria:

- None

Contacts and Locations
Contacts

Contact: Jiyan Chen, Doctor chenjiyandr@126.com

Contact: Yong Liu, Doctor liuyong2099@126.com

Locations

China, Guangdong
Dongguan People's Hospital
Dongguan

China, Guangdong
The First People's Hospital of Shunde Foshan
Foshan

China, Guangdong
Guangdong General Hospital
Guangzhou

China, Guangdong
Guangzhou Panyu Central Hospital
Guangzhou

China, Guangdong
Maoming People's Hospital
Maoming

Sponsors and Collaborators

Guangdong Provincial People's Hospital

Maoming People's Hospital

Dongguan People's Hospital

First People's Hospital, Shunde China

Guangzhou Panyu Central Hospital

Investigators

Principal Investigator: Yan Liang Maoming People's Hospital

Principal Investigator: Jianfeng Ye Dongguan People's Hospital

Principal Investigator: Yunzhao Hu The first People's Hospital of Shunde, Foshan

Principal Investigator: Wenzhu Zhang Guangzhou Panyu Central Hospital

More Information