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Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 06/15/2021.

Dose-effect Relationship Between microRNAs in Peripheral Blood and Radiation Injury

Clinicaltrials.gov identifier NCT03928782

Recruitment Status Recruiting

First Posted April 26, 2019

Last update posted April 26, 2019

Study Description

Brief summary:

Rapid and accurate assessment of radiation injury dose is the key to success in early treatment and an urgent issue to be solved in clinical medicine.Researches showed that the expression of the microRNAs in human peripheral blood had much correlation with radiation injury resulted from different dosages of radiation.In this study,acute leukemic patients who will be pretreated by whole-body radiation are taked as the object of study,and biochip technology are adopted to detect the expression levels of the microRNAs in subject peripheral blood before-and-after radiation,and different expression is tested and Bioinformatics prediction,to evaluate the correlation between radiation injury dose and expression levels of the microRNAs in human peripheral blood.

  • Condition or Disease:Radiation Injuries, Experimental
  • Intervention/Treatment: Radiation: 5 Gy or 10 Gy units of whole-body radiation
  • Phase: N/A
Detailed Description

N/A

Study Design
  • Study Type: Observational
  • Estimated Enrollment: 8 participants
  • Observational Model: Case-Only
  • Time Perspective: Prospective
  • Official Title: Study on Dose-effect Relationship Between Radiation Injury Dose and Expression of Associated microRNAs in Human Peripheral Blood
  • Actual Study Start Date: December 2018
  • Estimated Primary Completion Date: July 2019
  • Estimated Study Completion Date: September 2019
Outcome Measures
  • Primary Outcome Measures: 1. expression levels of the microRNAs [ Time Frame: 12 hours ]
    the expression levels of the microRNAs in human peripheral blood before radiation,12 hours after radiation and 24 hours after radiation
Eligibility Criteria
  • Ages Eligible for Study: 18 to 50 Years (Adult)
  • Sexes Eligible for Study: All
  • Accepts Healthy Volunteers:
  • Sampling Method: Non-Probability Sample
  • Study Population: Acute leukemic patients after chemotherapy,who will be pretreated by whole-body irradiation
Criteria

Inclusion Criteria:

- subjects who suffer from acute leukemic subjects who accept chemotherapy within one
month and will be pretreated by whole-body irradiation peripheral blood cells of
subjects are approximate to those of healthy person aged between 18 and 50 years old
subjects who are competent to give written informed consent subjects without other
systemic diseases

Exclusion Criteria:

- subjects who suffer from serious other systemic diseases subjects who are unwilling or
unable to cooperate with this clinical study other serious cases that probably hinder
this clinical study

Contacts and Locations
Contacts

Contact: Guo biao, master 0086-010-66947095 418406096@qq.com

Contact: Lu rongjian, doctor 0086-010-66947334 13426301158@163.com

Locations

China, Beijing
Chiese PLA 307 hospital
Beijing

China, Beijing
Chiese PLA 307 hospital
Beijing

Sponsors and Collaborators

Affiliated Hospital to Academy of Military Medical Sciences

Investigators

Study Chair: Lu rongjian, doctor Chinese PLA 307 Hospital

Study Director: Guo biao, master Chinese PLA 307 Hospital

More Information
  • Responsible Party: Affiliated Hospital to Academy of Military Medical Sciences
  • ClinicalTrials.gov Identifier: NCT03928782 History of Changes
  • Other Study ID Numbers: KY-2018-4-26
  • First Posted: April 26, 2019 Key Record Dates
  • Last Update Posted: April 26, 2019
  • Last Verified: April 2019
  • Studies a U.S. FDA-regulated Drug Product: No
  • Studies a U.S. FDA-regulated Device Product: No
  • Keywords provided by Affiliated Hospital to Academy of Military Medical Sciences: microRNA Radiation Injuries
  • Additional relevant MeSH terms: Wounds and Injuries
    Radiation Injuries
    Radiation Injuries, Experimental