April 26, 2019
March 2, 2021
The study will test a real-time functional magnetic resonance imaging (fMRI) hyperscanning neurofeedback protocol for feasibility with ten mothers and their psychiatrically healthy adolescent daughters, with the eventual goal to test this in a sample of depressed adolescents in a future study.
This study will utilize a rigorous multi-method, multi-informant design to examine the effects of dyadic neurofeedback (dnf) on adolescent brain activation with fMRI hyperscanning. Parents and adolescents will also report on emotion regulation, depressive symptoms, and parenting practices. Data collection procedures will take place at the Laureate Institute for Brain Research (LIBR), which is equipped with two identical scanners that have advanced real-time fMRI systems capable of conducting parallel fMRI hyperscanning, including the capacity for neurofeedback. Parents will complete a phone screen to determine initial eligibility. If initial study criteria are met, a 2-hour in-person lab visit will be scheduled where mothers and daughters will complete consent/assent; diagnostic interviews; surveys on emotion regulation, parenting practices, depression, and anxiety; and additional screening. Survey data will be used for preliminary exploratory analyses. Based on data collected from the screening visit, participants will be invited to participate in the full study: a 4-hour visit where mothers and daughters will complete emotion ratings, mock scanner training, and fMRI tasks individually and together using hyperscanning (scan time = 16 min resting-state [2 runs], 7 min structural MRI, 40 min fMRI tasks, 10 min clinical MRI scans).
|Experimental: Real-time fMRI neurofeedback
All participants will receive neurofeedback from the target region (no sham condition).
Behavioral: Real-time fMRI neurofeedback
Participants will attempt to regulate own and/or their partner's brain activation in a specified brain region via real-time fMRI neurofeedback.
- Eligible for fMRI
- Sufficient English fluency to complete tasks
- BMI ≦ 40.0
- Biological female
- Co-residing at least 4 days/week
- Adult participants: Biological mother of adolescent participant
- Adult participants:Primary caregiver > 50% of child's lifespan
- Adult participants:BMI ≧ 18.0
- Adolescent participants: Age 13-17 years
- Adolescent participants: BMI ≧ 16.0
- Current psychiatric diagnosis
- Medications influencing fMRI
- Medical conditions influencing fMRI
- Alcohol or psychoactive drug on scan day
- Adolescent participants: Neurodevelopmental delay
- Adolescent participants: History of mood or psychotic disorder
- Adolescent participants: History of obsessive-compulsive disorder (OCD) or
attention-deficit/hyperactivity disorder (ADHD)
Contact: Kara L Kerr, PhD (405) 332-6746 firstname.lastname@example.org
Contact: Amanda Morris, PhD (918) 594-8207 email@example.com
United States, Oklahoma
Laureate Institute for Brain Research
Oklahoma State University
Principal Investigator: Kara L Kerr, PhD Oklahoma State University