May 1, 2019
November 4, 2020
The main objective of the trial is to evaluate the effect of point-of-care testing of respiratory pathogens at a pediatric emergency room on the antibiotic consumption and hospital admissions in acutely ill children.
The study is a randomized controlled trial including children 0 up to 17 years of age with fever or acute respiratory infection at a pediatric emergency department in university hospital. In total 1668 subjects will be randomly allocated to undergo point-of-care multiplex respiratory pathogen testing with results ready within approximately one hour or to a control group with testing according to clinical judgement and results ready within next office day. Subjects will be randomized on admission and unequal allocation ratio of 2:1 (1112 subjects to intervention and 556 subjects to control arm) will be used. Data on rate of hospitalization, antibiotic prescriptions, ancillary testing and length of visit will be collected using medical record system.
|Experimental: Point-of-care testing of respiratory pathogens on admission
Point-of-care testing of respiratory pathogens on admission. The subjects will receive the point-of-care testing of respiratory pathogens at pediatric emergency room. The results are ready within 1 one hour.
Diagnostic Test: QIAstat at pediatric emergency room
Pediatric acute care nurses will obtain respiratory samples for testing from all patients with fever or any respiratory symptom.
- Any respiratory symptom defined as tachypnea, shortness of breath, apnea, wheezing,
cough, rhinitis, croup, sneezing, ear ache, or sore throat AND/OR
- Fever > 38.0 C
- Need of resuscitation at emergency room
- Need of immediate transfer to pediatric intensive care unit
Department of Pediatrics, Oulu University Hospital
University of Oulu
Oulu University Hospital
Principal Investigator: Terhi S Tapiainen, MD,PhD Oulu University Hospital