Uncontrolled Donation After Circulatory Determination of Death (uDCDD)
Clinicaltrials.gov identifier recruitment status First Posted Last update posted
NCT03935230 Completed May 2, 2019 May 2, 2019

study description
Brief Summary

World-wide, patients waiting for organ transplantation exceed the number of organs available. Many European countries have a uDCDD program which contribute to 10-15% of the donor pool. In Canada, this type of program does not exist. The purpose of this study is to report how many deceased person fulfill the criteria for uncontrolled DCDD in a Canadian medical center.

Condition or Disease: Uncontrolled Donation After Circulatory Determination of Death
Intervention/treatment:
Phase: N/A
Detailed Description

While transplantation has become the definitive treatment for many people suffering end-stage
organ failure, demand exceeds supply. For many years, donation after neurological death
represented the principal source of organs for transplantation. In the last decade,
prevention measures, improvements in neurocritical care, and decompressive craniectomy have
led to a significant decrease in the number of non-directed donors (NDDs). In such
situations, alternative sources for organ donation must be identified. Cardiac-arrest
patients could provide a solution to this organ shortage. Patients who have experienced
unexpected in or out of hospital cardiopulmonary arrest could become organ donors. Organ
donation following uncontrolled cardiocirculatory death is currently practiced in many
European countries. However, in Canada, it's not yet authorized. Yet, each deceased could
save up to four lives. The purpose of this study is to determine the organ potential for a
cohort of patient who had died from a cardiopulmonary arrest at the CHUS in 2015 and assess
the effect of the implementation of a uDCD program on the number of additional donors.


study design
Study Type: Observational
Estimated Enrollment : 1111 participants
Intervention Model : N/A
Masking: N/A
Primary Purpose: N/A
Official Title: Uncontrolled Donation After Circulatory Determination of Death (uDCDD): A Potential Solution to the Shortage of Organs in Quebec?
Actual Study Start Date: May 2016
Actual Primary Completion Date: August 2016
Actual Study Completion Date: August 2016
outcome measures
Primary Outcome Measures: 1. Potential contribution of a uDCDD program on the number of additional donors. [ Time Frame: 1 year ]
Defined as (must meet all criteria): Age ≤70 years old Absence of obvious cause of death (rigor mortis, decapitation, overwhelming traumatic injury) Absence of surgical cause of cardiac arrest No sign of IV drug abuse No history of malignancies
Secondary Outcome Measures: 1. Effect of the implementation of a uDCDD program on the number of additional organs suitable for transplantation. [ Time Frame: 1 year ]
Effect of the implementation of a uDCDD program on the number of additional organs suitable for transplantation.
2. Number of tissus donors [ Time Frame: 1 year ]
Number of tissus donors
3. Potential obstacles and solutions related to the implementation of a uDCDD program in Canada. [ Time Frame: 1 year ]
Potential obstacles and solutions related to the implementation of a uDCDD program in Canada.
4. Areas of future research. [ Time Frame: 1 year ]
Areas of future research.

Eligibility Criteria
Ages Eligible for Study: 18 to 65 Years (Adult, Older Adult)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Criteria

Inclusion Criteria:

- All patients treated for cardiocirculatory arrest at the CIUSSS-Estrie CHUS in 2015.

Exclusion Criteria:

- Patients with a status of no resuscitation

- Pediatric patients (65 years old


Contacts and Locations
Contacts
Locations
Sponsors and Collaborators
Université de Sherbrooke
Investigator
Principal Investigator : Frédérick D'Aragon, Dr/Pr Université de Sherbrooke
More Information
Responsible Party : Université de Sherbrooke
ClinicalTrials.gov Identifier : NCT03935230     
Other Study ID Numbers : 2016-1416
First Posted : May 2, 2019
Last Update Posted : May 2, 2019
Last Verified : June 2016
Individual Participant
Data (IPD) Sharing
Statement:
 
Plan to Share IPD: No
Keywords provided by Université de Sherbrooke: potential organ donors unexpected cardiopulmonary arrest
Additional relevant MeSH terms :
Death