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Currently, you can access the following clinical trials being conducted worldwide:
Clinicaltrials.gov identifier NCT03937804
Recruitment Status Recruiting
First Posted May 6, 2019
Last update posted October 8, 2020
Background: Some groups of people have a high prevalence of asthma and allergic disease. Also, asthma and allergic disease are often found in several members of the same family. Researchers want to learn more about what factors might cause asthma, both genetic and environmental. Objective: To build a collection of information to try to find genes that cause conditions and disorders such as asthma and allergic disease. Eligibility: People ages 18 99 of self-identified African, African American, or African Caribbean descent who either have no history of asthma or wheeze or have a physician s diagnosis of asthma Design: Participants will be screened with an interview by phone or in person. Participants will fill out a questionnaire about their general health and exposure to allergens and smoke. Participants will have a physical exam. Participants will have blood tests. Participants will provide a skin cell sample. Up to two samples will be taken from the inside of the nose. A brush will be used to take the samples. Participants will have a breathing test. They will be asked to blow forcefully 3 or more times into a lung function machine. Participants may have their blood and skin samples sent to a lab. DNA will be extracted from the samples and tested. Participants blood and skin samples will be stored. Samples may be used in future research studies.
Asthma is a complex disease where the interplay between genetic factors and environmental exposures controls susceptibility and disease progression. In the U.S., there remains an epidemic of asthma that disproportionately affects underrepresented minorities and creates a major public health burden, especially among children. Asthmatics of African ancestry continue to have more severe asthma and more severe clinical symptoms than their non-African counterparts, but few studies have focused on this vulnerable group. The purpose of this study is to expand our previous study, the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) to integrate multi-omic resources for asthma research in African Diaspora populations and by recruiting new participants. The protocol described herein refers to the recruitment that will take place at the NIH Clinical Center as part of the expansion of CAAPA (CAAPA2).
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, , Learn About Clinical Studies.-->
- INCLUSION CRITERIA:
Individuals age 18 to 99 of self-identified African, African American, or African Caribbean
ancestry who either have no history of asthma or wheeze (controls) or have a physician s
diagnosis of asthma. This study focuses exclusively on African ancestry individuals in
order to address a lack in the field of asthma research focusing on those of African
ancestry despite the greater disease burden experienced by these individuals. Enrollment
for the CAAPA2 study at the NIH CC will include only adults, while children will be
enrolled at other CAAPA2 sites, consistent with expertise at those sites. Pregnant women
are included as study procedures remain of minimal risk to these women. However, as the
size of the growing fetus may cause mechanical difficulties in performing the pulmonary
function test optimally for women at later stages of pregnancy, women who self-report
pregnancy at either second or third trimester will be asked to return for testing after
delivery, if they are still interested in participating.
- First degree relative of enrolled study participant (as determined through responses
to a screening questionnaire to question on participation of parents, siblings, or
- Current and active smoker
- History of: chronic obstructive pulmonary disease, chronic obstructive airway disease,
emphysema, chronic bronchitis, lung transplant, kyphoscoliosis, sarcoidosis,
bronchopulmonary dysplasia, cystic fibrosis, bronchiectasis, rheumatoid arthritis,
Crohn s disease, psoriasis, carcinoma of the lung, ciliary dyskinesia, lupus, or
- Having any medical illnesses that would increase the risk that the participant would
incur by participating in the study, interfere with the outcomes of the study, or
interfere with the study procedures (evaluated using Spirometry Screener.
Contact: Hermon Feron (301) 480-8149 firstname.lastname@example.org
United States, Maryland
National Institutes of Health Clinical Center
National Human Genome Research Institute (NHGRI)
Principal Investigator: Charles N Rotimi, M.D. National Human Genome Research Institute (NHGRI)