- Solid Tumors
- Pipeline Molecules
- Alliance Partners
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Currently, you can access the following clinical trials being conducted worldwide:
Clinicaltrials.gov identifier NCT03938766
Recruitment Status Completed
First Posted May 6, 2019
Last update posted February 12, 2020
Prostate specific membrane antigen (PSMA) is a unique membrane bound glycoprotein, which is overexpressed on prostate cancer cells and is well-characterized as an imaging biomarker of prostate cancer. Studies have shown that PSMA PET/CT can detect prostate cancer lesions with excellent contrast and a high detection rate even when the level of prostate specific antigen is low. PSMA imaging is considered the gold standard in imaging of biochemical recurrence, with detection rate of recurrence in 79.5% of patients, in the largest series of 1007 patients. Despite these excellent results, there remains approximately 20% of patients in whom the site of biochemical recurrence cannot be identified and further research is needed into improving detection rates. Androgen deprivation therapy (ADT), represents the standard of care treatment for most men with a rising serum PSA and no evidence of disseminated disease on imaging modalities. There has been some preliminary data that imaging patients early after initiation of ADT therapy may increase detection rates of recurrence sites. The objective of this study is to evaluate if prostate cancer patients with biochemical recurrence and negative PSMA PET/CT can demonstrate in-vivo upregulation of PSMA receptors in an attempt to improve detection rates of recurrent prostate cancer. Patients who are started on ADT when clinically indicated, will have repeat PSMA PET/CT at 4 weeks following initiation of ADT therapy.
|Other: PSMA PET/CT
Repeat PSMA PET/CT after ADT
Diagnostic Test: PSMA PET/CT
Repeat PSMA PET/CT 4 weeks post initiation of clinically indicated ADT in patients with prior negative PSMA PET/CT performed for biochemical recurrence.
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, , Learn About Clinical Studies.-->
- Male sex
- Age 18 years or older
- Previous diagnosis of prostate cancer following radical prostatectomy or primary
radiation therapy, with biochemical recurrence.
- Prior negative PSMA PET/CT within 2 months prior to study entry
- ECOG performance status 0 - 3, inclusive
- Able to understand and provide written informed consent
- Initiation of androgen deprivation therapy within 5 weeks prior to study PSMA PET/CT
- Able to tolerate the physical/logistical requirements of a PET/CT scan
- Medically unstable patients
- Patients who exceed the safe weight limit of the PET/CT bed (200 kg) or who cannot fit
through the PET/CT bore (70 cm diameter)
- Patients with unmanageable claustrophobia
Jewish General Hospital
Jewish General Hospital