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Currently, you can access the following clinical trials being conducted worldwide:
Clinicaltrials.gov identifier NCT03939390
Recruitment Status Recruiting
First Posted May 6, 2019
Last update posted June 23, 2020
This study aims to investigate the difference in the number of oocytes obtained by performing ovarian stimulation in follicular phase vs. luteal phase in a population of patients with previous suboptimal response. This is a controlled randomized clinical study. We aim to include 41 patients diagnosed with suboptimal response who will undergo an ovarian stimulation in order to vitrify and accumulate oocytes. The main variable for evaluating the efficacy in this exploratory study will be the number of oocyte cumulus complexes obtained.
|Experimental: luteal phase stimulation
Drug: time of administration of Corifollitropin Alfa
The treatment will be identical in both arms. The difference between the arms is the moment of the Administration of Corifollitropin Alfa: follicular phase of the menstrual cycle (control group) vs. luteal phase of the menstrual cycle (study group).
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- Meets Bologna criteria to be diagnosed as poor responder
- Less than 10 oocytes obtained in a prior controlled protocol of conventional ovarian
- Age < 41 years - Body Mass Index (BMI) between 18 and 32 kg/m2 - Regular menstrual cycles between 21 and 35 days. - Indication for in vitro fertilization - Indication to start stimulation with 150mcg of corifollitropin alpha - Presence of both ovaries - Ability to participate and comply with study protocol - Signing an informed consent form Exclusion Criteria: - Presence of follicles larger than 10 mm in the randomization visit - Endometriosis stage III/IV - Patients with less than 4 oocytes in previous ovarian stimulation and poor ovarian reserve parameters (as per Bologna criteria) - Concurrent participation in another study
Contact: Anna Pitas, PhD +34663926079 firstname.lastname@example.org