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Currently, you can access the following clinical trials being conducted worldwide:
Clinicaltrials.gov identifier NCT03945526
Recruitment Status Completed
First Posted May 10, 2019
Last update posted May 13, 2019
This is an interventional randomized, controlled trial in analyzing the effects of astaxanthin supplementation on plasma malondialdehyde levels and NIHSS of acute ischemic stroke patients. According to published studies, it was hypothesized that acute ischemic stroke patients who were given astaxanthin would have lower plasma malondialdehyde levels and lower NIHSS score compared to the control group.
There were a total of 24 subjects, with 12 subjects in the intervention group and 12 subjects in the control group.The participants were divided into an interventional group and a control group. The interventional group was given astaxanthin supplementation 2 x 8mg per day for 7 days, while the control group was given placebo.
|Active Comparator: Astaxanthin
Astaxanthin supplementation will be given at 2 x 8mg for 7 days.
|Placebo Comparator: Control
A placebo will be given, which takes the form of a drug with the exact same shape and color as astaxanthin supplementation
Drug: Placebo Oral Tablet
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, , Learn About Clinical Studies.-->
- 40-65 years old
- Has acute ischemic stroke with an onset of less than 48 hours before hospital
- NIHSS score of less than or equal to 15
- Can consume food orally or enterally
- Has given their consent to be a participant in the study
- Renal failure
- Liver failure
- Is taking supplements other than his or her main stroke medications
- Has taken antioxidant supplements in the last 3 months before stroke onset
Department of Nutrition University of Indonesia
Study Chair: Salim Harris, SpS IDI
Study Chair: Sri Sukmaniah, SpGK IDI
Shen H, Kuo CC, Chou J, Delvolve A, Jackson SN, Post J, Woods AS, Hoffer BJ, Wang Y, Harvey BK. Astaxanthin reduces ischemic brain injury in adult rats. FASEB J. 2009 Jun;23(6):1958-68. doi: 10.1096/fj.08-123281. Epub 2009 Feb 13.
Demirkaya S, Topcuoglu MA, Aydin A, Ulas UH, Isimer AI, Vural O. Malondialdehyde, glutathione peroxidase and superoxide dismutase in peripheral blood erythrocytes of patients with acute cerebral ischemia. Eur J Neurol. 2001 Jan;8(1):43-51.