About Bolder Science

Our mission is to provide healthcare professionals with unbiased clinical research information, easily.

Currently, you can access the following clinical trials being conducted worldwide:

359,057 studies
in
219 countries
Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 01/21/2021.
This website is for US healthcare professionals

Log In to Bolder Science

or

Don't have an account? Sign Up

Please enter your email address.

You will receive a link to create a new password via email.

Log In

Create an Account

or
(optional) ?

Welcome, !

Please complete the following 4 questions to ensure you receive the information that best suits your needs.

Clinical Trials of Interest

When I’m looking for information on clinical trials, I usually am interested in...

finding clinical trials in which to enroll my patients

Rarely Often

finding newly launched clinical trials (for all phases)

Rarely Often

updates on status changes for clinical trials

Rarely Often

pipeline molecules

Rarely Often

Drug Interventions

Enter up to 3 drug interventions you are currently interested in:

Clinical trial information and results are updated daily from ClinicalTrials.gov. The latest data update was conducted on 01/21/2021.

Comparison of the PaO2/FiO2 Ratio to Other Oxygenation Indexes for the Classification of Severity of Acute Respiratory Distress Syndrome

Clinicaltrials.gov identifier NCT03946189

Recruitment Status Completed

First Posted May 10, 2019

Last update posted May 10, 2019

Study Description

Brief summary:

In mechanically ventilated patients the PaO2/FiO2 ratio might not be the best reflection of the severity of ARDS. It does not incorporate variables and settings used during mechanical ventilatory support such as the positive end expiratory pressure (PEEP), inspiratory time to expiratory time ratio (Ti:Te), and the peak alveolar pressure (Palv). The aim is to identify a new oxygenation index for stratification of severity of ARDS

  • Condition or Disease:Acute Respiratory Distress Syndrome
  • Intervention/Treatment: Diagnostic Test: Obtaining arterial blood gases
  • Phase: N/A
Detailed Description

N/A

Study Design
  • Study Type: Observational
  • Actual Enrollment: 150 participants
  • Observational Model: Cohort
  • Time Perspective: Prospective
  • Official Title: Comparison of the PaO2/FiO2 Ratio to Other Oxygenation Indexes for the Classification of Severity of Acute Respiratory Distress Syndrome
  • Actual Study Start Date: March 2018
  • Actual Primary Completion Date: May 2019
  • Actual Study Completion Date: May 2019
Groups and Cohorts
Groups/Cohorts Intervention/treatment
: P/F between 100 and 200
Patients receiving mechanical ventilation with paO2/FiO2 between 100 and 200
Diagnostic Test: Obtaining arterial blood gases
Obtaining arterial blood sample
: P/F between 200-300
Patients receiving mechanical ventilation with paO2/FiO2 between 200 and 300
Diagnostic Test: Obtaining arterial blood gases
Obtaining arterial blood sample
: P/F less than 100
Patients receiving mechanical ventilation with paO2/FiO2 less than 100
Diagnostic Test: Obtaining arterial blood gases
Obtaining arterial blood sample
Outcome Measures
  • Primary Outcome Measures: 1. New oxygenation index [ Time Frame: Immediate ]
    Oxygenation index that incorporates ventilator parameters
Eligibility Criteria
  • Ages Eligible for Study: 18 to 65 Years (Adult, Older Adult)
  • Sexes Eligible for Study: All
  • Accepts Healthy Volunteers:
  • Sampling Method: Non-Probability Sample
  • Study Population: Patients of both gender and greater than 18 years old receiving mechanical ventilation in the ICU
Criteria

Inclusion Criteria:

- Patients receiving mechanical ventilation in the Intensive Care Unit.

- Patients in whom the managing medical team requested an arterial blood gas (ABG)
analysis.

Exclusion Criteria:

- Patients in whom arterial blood gas could not be obtained or not ordered.

Contacts and Locations
Contacts
Locations

Lebanon
American University of Beirut
Beirut

Sponsors and Collaborators

American University of Beirut Medical Center

More Information
  • Responsible Party: American University of Beirut Medical Center
  • ClinicalTrials.gov Identifier: NCT03946189 History of Changes
  • Other Study ID Numbers: BIO-2018-0033
  • First Posted: May 10, 2019 Key Record Dates
  • Last Update Posted: May 10, 2019
  • Last Verified: May 2019
  • Individual Participant
    Data (IPD) Sharing
    Statement:
  • Plan to Share IPD: Undecided
  • Studies a U.S. FDA-regulated Drug Product: No
  • Studies a U.S. FDA-regulated Device Product: No
  • Additional relevant MeSH terms: Acute Lung Injury
    Syndrome
    Respiratory Distress Syndrome, Newborn
    Respiratory Distress Syndrome, Adult